17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume II) (2024) [O-19-P, pp. 659-662]
AUTHOR(S) / АУТОР(И): Danina Krajišnik 
, Snežana Uskoković-Marković , Aleksandra Daković , Marija Marković
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DOI: 10.46793/Phys.Chem24II.659K
ABSTRACT / САЖЕТАК:
In this study, the preparation and characterization of chitosan–clay composites prepared at different polymer–clay mass ratios, were performed as potential carriers for tetracycline hydrochloride. The composites based on bentonite (from Beretnica deposit, Republic of Serbia) and low molecular weight chitosan were prepared. Adsorption of tetracycline was investigated at the different initial concentrations (0.5 – 1 mg/mL) at pH 3.4. Characterization of the chitosan–clay composites before and after adsorption of tetracycline was performed by determination of the zeta potential and by FTIR spectroscopy. The characterization results confirmed the presence of polymer and tetracycline on the clay surface. The amounts of adsorbed antibiotic were influenced by the polymer–clay mass ratio, i.e. the presence of chitosan in the composites.
KEYWORDS / КЉУЧНЕ РЕЧИ:
ACKNOWLEDGEMENT / ПРОЈЕКАТ:
This research was funded by the Science Fund of the Republic of Serbia, #GRANT No 7748088, Project title: Composite clays as advanced materials in animal nutrition and biomedicine – AniNutBiomedCLAYs.the Ministry of Science, Technological Development and Innovation, and by the Republic of Serbia through the following Grant Agreements: 451-03-65/2024-03/200161 and 451-03-66/2024-03/200161 (University of Belgrade-Faculty of Pharmacy).
REFERENCES / ЛИТЕРАТУРА:
- L. Giuseppe, S. Riela, R.F. Fakhrullin, Ther. Deliv., 8(8) 2017 633.
- M. H. Kim, G. Choi, A. Elzatahry, A. Vinu, Y. B. Choy, J. H. Choy, Clays Clay Miner., 64(2) (2016) 115.
- Y. Wang, Z. Wang, W. Lu, Y. Hu, Int. J. Biol. Macromol., (2023) 128080.
- D. Krajišnik, S. Uskoković-Marković, A. Daković, D. Smiljanić, M. Kozarski, V. Lazić in: 5th Metallurgical & Materials Engineering Congress of South-East Europe, Trebinje, BIH (2023) 123.