17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume II) (2024) [O-11-P, pp. 627-630]
AUTHOR(S) / AUTOR(I): Dunja Jovanović 
, Ana Filipović , Zdravko Džambaski , Bojan P. Bondžić and Aleksandra M. Bondžić
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DOI: 10.46793/Phys.Chem24II.627J
ABSTRACT / SAŽETAK:
Lipophilicity expressed by the n-octanol/water partition coefficient, logPo/w, is one of the physicochemical properties of the drug that determines its solubility, the ability to penetrate through cell barriers, and the probability of transport to the molecular target. It also affects pharmacokinetic processes such as adsorption, distribution, metabolism and excretion of a drug. The aim of this study was to evaluate the influence of substitution with different functional groups of biologically active N-aryl-tetrahydroisoquinoline derivatives (THIQs) on the logPo/w. The logPo/w for a set of six N-aryl-tetrahydroisoquinoline derivatives was estimated using reversed-phase ultra performance liquid chromatography (RP-UPLC) technique using a C18 column as a stationary phase and water/acetonitrile mixtures as mobile phases.
KEYWORDS / KLJUČNE REČI:
ACKNOWLEDGEMENT / PROJEKAT:
This work was supported by the Ministry of Science, Technological Development, and Innovation of the Republic of Serbia (Agreement No. 451-03-66/2024-03/200017 and 451-03-66/2024- 03/200026).
REFERENCES / LITERATURA:
- D. Jovanović, A. Filipović, G. Janjić, T. Lazarević-Pašti, Z. Džambaski, B. P. Bondžić, A. M. Bondžić, Int J Mol Sci, 25 (2024) 1033.
- J. X. Soares, Á. Santos, C. Fernandes, M. M. M. Pinto, Chemosensors, 10 (2022) 340.