THE EFFECT OF NONIONIC BRIJ 35 MICELLES ON THE IONIZATION OF SOME DRUGS USED IN THE TREATMENT OF ALERGIC REACTIONS

17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume II) (2024) [O-08-P, pp. 615-618]  

AUTHOR(S) / АУТОР(И): Marija Popović-Nikolić , Slavica Oljačić and Gordana Popović

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DOI: 10.46793/Phys.Chem24II.615PN

ABSTRACT / САЖЕТАК:

The pKa values of four compounds used in the treatment of allergic reactions, bilastine, cetirizine, montelukast and rupatadine have been potentiometrically determined in micellar solutions of nonionic surfactant Brij 35. Nonionic micelles affected the ionization of investigated compounds from -1.97 to +2.51 pKa units comparing to “pure” water. The most significant changes in distribution of the equilibrium forms are observed at pH values of biopharmaceutical importance which may indicate on potential interactions with noncharged but polar molecules under the physiological conditions.

KEYWORDS / КЉУЧНЕ РЕЧИ:

ACKNOWLEDGEMENT / ПРОЈЕКАТ:

This research was funded by the Ministry of Science, Technological Development and Innovation, Republic of Serbia through two Grant Agreements with University of Belgrade-Faculty of Pharmacy No 451-03-65/2024-03/200161 and No 451-03-66/2024-03/ 200161. The authors thank the COST Actions CA18240, CA18133 and CA22125 of the European Community for support.

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