17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume II) (2024) [O-05-P, pp. 603-606]
AUTHOR(S) / AUTOR(I): Mirjana B. Čolović 
, Jelena J. Žakula , Lela B. Korićanac , Nada Savić , Tatjana Parac-Vogt and Danijela Z. Krstić
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DOI: 10.46793/Phys.Chem24II.603C
ABSTRACT / SAŽETAK:
The influence of L(+)-ascorbic acid sodium salt (ascorbate), as a widely used antioxidant, on the anti-human melanoma A375 activity of a monolacunary Wells-Dawson polyoxometalate (mono- WD), α2-K10P2W17O61.20H2O was assessed in this study. A375 cells were in vitro exposed to the selected concentrations of mono-WD (the concentration range of 0.001 – 1 mM), ascorbate (0.040 – 40 mM), and the mixtures of mono-WD and ascorbate in the ratio of 1:40, for 24 and 48 hours. Both mono-WD and ascorbate induced concentration- dependent cytotoxic effects on A375 tumour cells, for both exposure times. The cell viability inhibiting potential of ascorbate was higher after 24-hour exposure, whereas similar cytotoxic effects of the studied compounds were obtained for 48- hour treatment. In summary, the results of the simultaneous exposure of A375 cells to mono-WD and ascorbate (mixed in the ratio of 1:40) showed that the presence of ascorbate does not affect remarkably the observed antitumour potency of the studied polyoxotungstate as a potential metallo- therapeutic.
KEYWORDS / KLJUČNE REČI:
ACKNOWLEDGEMENT / PROJEKAT:
This study was financially supported by the Ministry of Science, Technological Development, and Innovation of the Republic of Serbia (contracts no. 451-03-66/2024-03/200017 and 451-03-9/2023- 14/200110). The authors are also thankful to the Science Fund of the Republic of Serbia (POMCACT project no. 6526393).
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