17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume II) (2024) [M-06-P, pp. 577-580]
AUTHOR(S) / AUTOR(I): Branka Dražić 
, Mirjana Antonijević Nikolić , Vojislav Stanić , Vesna Stojiljković and Slađana Tanasković
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DOI: 10.46793/Phys.Chem24II.577D
ABSTRACT / SAŽETAK:
Five binuclear complexes with general formula [Cu2(L)tpmc](ClO4)4, L= valine (1), norvaline (2) leucine (3), norleucine (4) and isoleucine (5) were tested in vitro against human tumor cell lines: THP-1 (human acute monocytic leukemic cell line), Jurkat (human acute T cell leukemia) and Ramos (B cells, Burkitt’s lymphoma cell line). The values of IC50 were calculated. All tested complexes showed significant activity against the tested lines. Complex 2 has promoted significant decreases in the metabolic activity of all three cell lines, especially according to Ramos (IC50 value is 40.21 ± 1.45 µM) and complex 3 of the Jurkat cells (IC50 value is 41.01 ± 1.71 µM). Results were compared with the analogous complexes with glycine and alanine as additional ligands.
KEYWORDS / KLJUČNE REČI:
ACKNOWLEDGEMENT / PROJEKAT:
This work was supported by the Ministry of Science, Technological Development and Innovation, Republic of Serbia (Grant No. 451-03-66/2024-03/200161).
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