INVESTIGATION OF THE RELEASE OF NOVEL ACRIDINE DERIVATIVE SUPPORTED ONTO Y ZEOLITE

17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume I) (2024) [H-12-P, pp. 321-324]  

AUTHOR(S) / АУТОР(И): Karmelina Teletina , Nikola Fišić , Maja Ranković , Jelena Rupar , Maja Milojević-Rakić , Anka Jevremović  

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DOI: 10.46793/Phys.Chem24I.321T

ABSTRACT / САЖЕТАК:

This study investigated 2-(acridin-9-ylamino)-3-(1H-indol-3-yl)propanoic acid, acridine derivative as a potential anticancer drug supported on FAU type zeolite Y. Y zeolite before and after the drug impregnation was characterized with the scanning electron microscopy and thermogravimetry, while HPLC/FL and spectrofluorimetry were employed for drug quantification. The morphology of the zeolite did not change during the drug impregnation process, and the resulting drug loading was 17.9 mg/g. The release of 1.2 µM acridine derivative concentration necessary for targeted cancer cytotoxicity and favorable kinetics was established for zeolite-supported acridine.

KEYWORDS / КЉУЧНЕ РЕЧИ:

ACKNOWLEDGEMENT / ПРОЈЕКАТ:

This research was funded by the Ministry of Science, Technological Development and Innovation of the Republic of Serbia, grant numbers 451-03-65/2024-03/200161, 451-03-65/2024-03/200146, and grant 04-4-1133-2018/2023 for collaboration between JINR, Dubna and University of Belgrade.

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