2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (321-325)
AUTOR(I) / AUTHOR(S): Sanja Lj. Matić, Tamara M. Mladenović, Milan P. Mladenović, Nevena M. Tomašević, Roberto Capobianco, Alessio Ragno, Filippo U. Sapienza, Roberta Astolfi, Rino Ragno
E-ADRESA / E-MAIL: sanjamatic@kg.ac.rs
DOI: 10.46793/ICCBI23.321M
SAŽETAK / ABSTRACT:
Pharmacological properties of essential oils of Pinus species are mainly associated with antimicrobial, antioxidant, anticancer, anti-aging, and anti-inflammatory potencies. However, only limited scientific information has been gathered regarding the genotoxic and antigenotoxic activities of Pinus essential oils. Therefore, the aim of the present study was to investigate the in vitro DNA protective activities of three commercial essential oils of Pinus species: P. mugo, P. sibirica, and P. silvestre, against the oxidative damage induced by hydroxyl and peroxyl radicals. The tested essential oils significantly reduced the DNA damage caused by the free radicals. Due to its capacity to decrease DNA damage, essential oils of Pinus species can be of great importance in clinical applications.
KLJUČNE REČI / KEYWORDS:
essential oils, DNA damage, free radicals, antigenotoxicity, Pinus
LITERATURA / REFERENCES:
- M. Basholli-Salihu, R. Schuster, A. Hajdari, D. Mulla, H. Viernstein, B. Mustafa, M. Mueller., Phytochemical composition, antiinflammatory activity and cytotoxic effects of essential oils from three Pinus spp., Pharmaceutical Biology, 55 (2017) 1553-1560.
- M. Paw, R. Gogoi, N. Sarma, S.K. Pandey, A. Borah, T. Begum, M. Lal., Study of anti-oxidant, antiinflammatory, genotoxicity, and antimicrobial activities and analysis of different constituents found in rhizome essential oil of Curcuma caesia Roxb., collected from north east India, Current Pharmaceutical Biotechnology, 21 (2020) 403–413.
- S. Garzoli, V.L. Masci, V. Caradonna, A. Tiezzi, P. Giacomello, E. Ovidi., Liquid and vapor phase of four conifer-derived essential oils: comparison of chemical compositions and antimicrobial and antioxidant properties, Pharmaceuticals 14 (2021) 134.
- A. Guri, P. Kefalas, V. Roussis., Antioxidant potential of six pine species, Phytotherapy Research, 20 (2006) 263–266.
- K. Li, Q. Li, J. Li, D. Gao, T. Zhang, Z. Han, F. Zheng., Effect of procyanidins from Pinus koraiensis bark on growth inhibition and expression of PCNA and TNF-a in mice with U14 cervical cancer, Therapy, 4 (2007) 685–690.
- E. Sezik, U. Osman, B. Demirci, K.H.C. Baser, Composition of the essential oils of Pinus nigra Arnold from Turkey, Turkish Journal of Chemistry, 34 (2010) 313-325.
- E. Dumitru, R. Dumitru., Terapia naturistă. incursiune in farmacia naturii; Editura Ştiinţifică: Bucharest, Romania, 1992.
- S. Vitalini, M. Iriti, C. Puricelli, D. Ciuchi, A. Segale, G. Fico., Traditional knowledge on medicinal and food plants used in Val San Giacomo (Sondrio, Italy)—An Alpine ethnobotanical study, Journal of Ethnopharmacology, 145 (2013) 517–529.
- M. Basholli-Salihu, R. Schuster, A. Hajdari, D. Mulla, H. Viernstein, B. Mustafa, M. Mueller., Phytochemical composition, anti-inflammatory activity and cytotoxic effects of essential oils from three Pinus spp., Pharmaceutical Biology, 55 (2017) 1553–1560.
- M. Bottoni, F. Milani, L. Colombo, K. Nallio, P.S. Colombo, C. Giuliani, P. Bruschi, G. Fico., Using medicinal plants in Valmalenco (Italian Alps): from tradition to scientific approaches, Molecules, 25 (2020) 4144.
- A.N. Shikov, V.G. Makarov, V.E. Ryzhenkov., Plant fixed oils and oil extracts: Technology, standardization, properties, Moscow: Publishing house Russian Doctor, (2004) 177-185,
- G.K. Silori, N. Kushwaha, V. Kumar., Essential oils from Pines: chemistry and applications. In: S. Malik (ed) essential oil research, trends in biosynthesis, analytics, industrial applications and biotechnological production. Springer, Cham., 2019.
- Y.W. Lin, Y.T. Wang, H.M. Chang, J.S.B. Wu., DNA protection and antitumor effect of water extract from residue of jelly fig (Ficus awkeotsang Makino) achenes, Journal of Food and Drug Analysis, 16 (2008) 63-69.
- L.L. Zhang, L.F. Zhang, J. G. Xu, Q. P. Hu., Comparison study on antioxidant, DNA damage protective and antibacterial activities of eugenol and isoeugenol against several foodborne pathogens, Food and Nutrition Research, 61 (2017), 1353356.
- C.A. Poorna, M. Resmi, E. Soniya., In vitro antioxidant analysis and the DNA damage protective activity of leaf extract of the Excoecaria agallocha linn Mangrove plant. In: Stoytcheva, M. (Ed.), Agricultural Chemistry. Intech, UK, 2013.