17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume II) (2024) [R-02-P, pp. 705-708]
AUTHOR(S) / АУТОР(И): Bojan Bondžić 
, Ana Filipović , Zdravko Džambaski , Marija Vučkovski and Aleksandra M. Bondžić
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DOI: 10.46793/Phys.Chem24II.705B
ABSTRACT / САЖЕТАК:
Functionalization of biologically important tetrahydroisoquinolines (THIQs) is achieved under visible light irradiation in the presence of Ir photocatalyst under microflow conditions. N– Benzoxazol and N-Benzthiazol substituted THIQs were alkylated at C1 position through Ir promoted C-H oxidation/organocatalyzed Mannich reaction sequence. Reactions were optimized in batch conditions regarding photo- and organocatalyst, temperature and light source and subsequently transferred to the custom-made polymeric type microreactor (polydimethylsiloxane polymer, PDMS). Application of the oxygen porous PDMS microreactor proved crucial regarding Ir catalyzed C-H oxidation step and overall reaction performance.
KEYWORDS / КЉУЧНЕ РЕЧИ:
ACKNOWLEDGEMENT / ПРОЈЕКАТ:
This work was supported by the Ministry of Science, Technological Development, and Innovation of the Republic of Serbia (Agreement No. 451-03-66/2024-03/200017 and 451-03-66/2024- 03/200026).
REFERENCES / ЛИТЕРАТУРА:
- M. R. Bennett, M. L. Thompson, S. A. Shepherd, M. S. Dunstan, A. J. Herbert, D. R. M. Smith, A. Cronin, B. R. K. Menon, C. Levy, J. Micklefield, Angew. Chem. Int. Ed., 57 (2018) 10600.
- C. S. Demmer, L. Bunch, Eur. J. Med. Chem. 97 (2015) 778.
- L. Ackermann, S. Barfusser, J. Pospech, Org. Lett. 12 (2010) 724.
- Y. Su, N. J. W. Straathof, V. Hessel, T. Noël, Chem. Eur. J. 20 (2014) 10562.