ACID BASE EQUILIBRIA OF OLOPATADINE IN AQUEOUS MEDIA

17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume II) (2024) [O-10-P, pp. 623-626]  

AUTHOR(S) / АУТОР(И): Marija Popović-Nikolić , Slavica Oljačić and Gordana Popović

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DOI: 10.46793/Phys.Chem24II.623PN

ABSTRACT / САЖЕТАК:

The pKa values of olopatadine were potentiometrically determined in the presence and in the absence of differently charged micelles, anionic, cationic and nonionic. The ionization of olopatadine has been significantly affected by the interactions of ionizable groups with micelles (∆pKa -2.21 to +2.75). All types of micelles caused an increase in the pKa of carboxylic group (∆pKa up to +2.75). Anionic and nonionic micelles contributed to the decrease (∆pKa up to -2.21), while cationic micelles caused the increase of the pKa value of tertiary amino group (∆pKa = +0.95). The most significant shift in distribution of equilibrium forms was observed in pH range 4 – 8.

KEYWORDS / КЉУЧНЕ РЕЧИ:

ACKNOWLEDGEMENT / ПРОЈЕКАТ:

This research was funded by the Ministry of Science, Technological Development and Innovation, Republic of Serbia through two Grant Agreements with University of Belgrade-Faculty of Pharmacy No 451-03-65/2024-03/200161 and No 451-03-66/2024-03/ 200161. The authors thank the COST Actions CA18240, CA18133 and CA22125 of the European Community for support.

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