17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume II) (2024) [O-09-P, pp. 619-622]
AUTHOR(S) / AUTOR(I): Marija Popović-Nikolić 
and Gordana Popović
Download Full Pdf 
DOI: 10.46793/Phys.Chem24II.619PN
ABSTRACT / SAŽETAK:
The protolytic equilibria of raloxifene were investigated in the presence of differently charged and/or polar micelles (CTAB, TX-100, Brij 35). The ionization constants were determined potentiometrically at a constant ionic strength (0.1 M NaCl) and temperature 25°C. In a relation to the pKa values previously determined in surfactant-free media, the presence of micelles caused a shift from -3.03 pKa to +3.12 pKa units. Significant changes in distribution of equilibrium forms at biopharmaceutically important pH values suggest on potential consideration of interactions between raloxifene and molecules present under the physiological conditions.
KEYWORDS / KLJUČNE REČI:
ACKNOWLEDGEMENT / PROJEKAT:
This research was funded by the Ministry of Science, Technological Development and Innovation, Republic of Serbia through two Grant Agreements with University of Belgrade-Faculty of Pharmacy No 451-03-65/2024-03/200161 and No 451-03-66/2024-03/ 200161. The authors thank the COST Actions CA18240, CA18133 and CA22125 of the European Community for support.
REFERENCES / LITERATURA:
- C. Ginsberg, J. H. Ix, Am. J. Kidney Dis., 79 (2022) 427.
- A. Ishani, T. Blackwell, S. A. Jamal, S. R. Cummings, K. E. Ensrud, J. Am. Soc. Nephrol., 19 (2008) 1430.
- N. M. Ağardan, Z. Değim, Ş. Yılmaz, L. Altıntaş, T. Topal, J. Drug Deliv. Sci. Technol., 57 (2020) 101612.
- J. H. Fendler, Chem. Rev., 87 (1987) 877.
- M. R. Popović-Nikolić, G. V. Popović, D. D. Agbaba, J. Chem. Eng. Data, 62 (2017) 1776.
- M. R. Popović-Nikolić, G. V. Popović, K. Stojilković, M.Dobrosavljević, D. D. Agbaba, J. Chem. Eng. Data, 63 (2018) 3150.
- M. R. Popović-Nikolić, M. Čakar, N. Todorović, K.Nikolić, G. Popović, Chem. Pap., 78 (2024) 4401.