17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume I) (2024) [E-09-P, pp. 203-206]
AUTHOR(S) / АУТОР(И): Mara Aleksić 
, Jelena Rupar , N. Vučković, L. Kováčiková, A. Boháč, V. Dobričić
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DOI: 10.46793/Phys.Chem24I.203A
ABSTRACT / САЖЕТАК:
Albumin is the most abundant protein in blood plasma and has a great ability to bind numerous molecules. Since inhibition of the enzyme aldose reductase can be used in the treatment of diabetes, it is important to investigate the interaction between albumin and aldose reductase inhibitors (ARI). The aim of this work is to investigate the electrochemical behavior of the newly synthesized potential ARI and to examine the possibility of studying the interaction of ARI with human serum albumin (HSA) by voltammetry.
The reduction of ARI is an irreversible, diffusion-controlled process. The application of the albumin-modified electrode showed no significant result in the investigation of the interaction of ARI and HSA. The study of the interaction in solution was difficult due to the poor solubility of ARI (poor reproducibility of signal). Due to the presence of polysorbate 80 in solution, satisfactory reproducibility was achieved and it was possible to detect the interaction of ARI and HSA.
KEYWORDS / КЉУЧНЕ РЕЧИ:
ACKNOWLEDGEMENT / ПРОЈЕКАТ:
This research was supported by the Ministry of Science, Technological Development and Innovation, Republic of Serbia through Grant Agreement with University of Belgrade-Faculty of Pharmacy No: 451-03-65/2024-03/ 200161
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