A Multi-Organ-on-a-Chip Platform for Modeling Cancer Metastasis

3rd International Conference on Chemo and BioInformatics, Kragujevac, September 25-26, 2025. (pp. 38-42) 

 

AUTOR(I) / AUTHOR(S): Amid Shakeri, Dhana Abdo, Matthew Ho Cheong Lei, Sargol Okhovatian, Richard Jiang, Chuan Liu, Karl T Wagner, Daniel Vosoughi, Jennifer Kieda, Milica Radisic

 

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DOI:  10.46793/ICCBIKG25.038S

SAŽETAK / ABSTRACT:

Understanding why certain organs such as heart resist cancer metastasis remains a major challenge in oncology. Here, we present a microphysiological platform capable of modeling multi-organ interactions under dynamic conditions. This system enables investigation of tissue-specific responses to cancer invasion and offers new opportunities for studying organ- selective mechanisms in disease progression.

KLJUČNE REČI / KEYWORDS:

cardiac tissue, metastasis, organ-on-a-chip, granular elastomer, 3D printing

PROJEKAT / ACKNOWLEDGEMENT:

LITERATURA / REFERENCES:

  • R. Bussani, F. De-Giorgio, A. Abbate, F. Silvestri, Journal of Clinical Pathology 2007, 60, 27.
  • L. Gómez-Cuadrado, N. Tracey, R. Ma, B. Qian, V. G. Brunton, Disease Models & Mechanisms 2017, 10, 1061.
  • S. Mi, Z. Du, Y. Xu, Z. Wu, X. Qian, M. Zhang, W. Sun, Scientific Reports 2016, 6, 35544.
  • A. Brooks, Y. Zhang, J. Chen, C.-X. Zhao, Advanced Healthcare Materials 2024, 13, 2302436.
  • L. Elkington, P. Adhikari, P. Pradhan, Biophysica 2022, 2, 59.