Sleep and the Gut

АУТОР(И) / AUTHOR(S): Alen Juginovic, Zhuojie Li, Alejandra Laureano, Andrea Mlinar, Dragana Rogulja

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DOI:  10.46793/ICCBIKG25.002J

САЖЕТАК / ABSTRACT:

Sustained sleep loss dramatically shortens lifespan, and clinical data link poor sleep with diseases like Diabetes, Alzheimer’s, cardiovascular disease, and cancer. The variety of problems suggests that multiple tissues might be affected, yet most efforts to understand sleep remain focused on the brain. The connection between sleep, health, and life itself remains one of the biggest unsolved biological mysteries. The team’s previous paradigm-shifting work revealed that severe sleep loss leads to high levels of reactive oxygen species (ROS) specifically in the gut, which causes gut damage and can result in early death. The overarching goal of the current work is to explain how sleep loss triggers ROS production, and how the consequent gut oxidation impacts the rest of the body. Using a combination of advanced genetic, genomic, and imaging techniques, the team will build a whole-body framework for understanding the detrimental effects of sleep restriction.

КЉУЧНЕ РЕЧИ / KEYWORDS:

sleep deprivation, gut, ROS

ПРОЈЕКАТ / ACKNOWLEDGEMENT:

This work was supported by the National Institutes of Health, USA.

ЛИТЕРАТУРА / REFERENCES:

• I. Titos, A. Juginovic, A. Vaccaro, P. Gorelik, O. Mazor, D. Rogulja. A gut-secreted peptide controls arousability from sleep, Cell, 186(7) (2023) 1382-1397.
• A. Vaccaro, Y. Kaplan Dor, K. Nambara, E.A. Pollina, C. Lin, M.E. Greenberg, D. Rogulja, Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut, Cell, 181(6) (2020) 1307-1328.