3rd International Conference on Chemo and BioInformatics, Kragujevac, September 25-26. 2025. (pp. 276-279)
АУТОР(И) / AUTHOR(S): Katarina G. Marković, Mirjana Ž. Grujović, Ana Kesić, Milica Paunović, Katarina Ćirković, Ivana Radojević, Nevena H. Djukić
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DOI: 10.46793/ICCBIKG25.276M
САЖЕТАК / ABSTRACT:
This study evaluates the cytotoxic and antibiofilm effects of silver nanoparticles (AgNPs) synthesised with aqueous and acetone extracts of Agrimonia eupatoria L. AgNPs significantly reduced HCT-116 colorectal cancer cell viability after 72 h, with AgNPs-acetone showing stronger effects but AgNPs-H₂O being more effective at lower doses. AgNPs-H₂O also inhibited biofilm formation by clinically relevant bacteria, with a wastewater isolate of Pseudomonas aeruginosa being the most sensitive. The results confirm the strain- and medium- specific activity of these AgNPs and support their potential as multifunctional anticancer and antibiofilm agents. Further studies are needed to assess their selectivity, safety, and mechanisms of action.
КЉУЧНЕ РЕЧИ / KEYWORDS:
silver nanoparticles, cell line, bacterial biofilm, antibiofilm activity
ПРОЈЕКАТ / ACKNOWLEDGEMENT:
This research is funded by the Ministry of Education and the Ministry of Science, Technological Development and Innovation of the Republic of Serbia (Grants 451-03- 136/2025-03/200378 and 451-03-137/2025-03/200122).
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