8th WORKSHOP: FOOD AND DRUG SAFETY AND QUALITY, (pp.159–162)
АУТОР / AUTHOR(S): M. B. Živković 
, S. J. Tufegdžić , S. B. Šegan , N. O. Đorđević , D. M. Sladić
DOI: 10.46793/8FDSQ.PC7MZ
САЖЕТАК / ABSTRACT:
In silico assessment of drug-likeness of 15 steroidal mono- and bis-thiazolidinones was performed. Androstrane (1−5) and progesterone types (6) mono-derivatives had no violations of Lipinski’s rule of five, while bis-derivatives had slightly higher molecular masses than 500 Da, and cholestane derivatives (8−9) showed high lipophilicity and Caco-2 permeability. All examined compounds showed great intestinal absorption potential.
КЉУЧНЕ РЕЧИ / KEYWORDS:
ПРОЈЕКАТ / ACKNOWLEDGEMENT:
This work was supported by the Ministry of Science, Technological Development and Innovation of the Republic of Serbia (Grants no. 451-03-66/2024-03/200026, and 451-03-66/2024-03/200017).
ЛИТЕРАТУРА / REFERENCES:
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