8th WORKSHOP: FOOD AND DRUG SAFETY AND QUALITY, (pp. 21–24)
АУТОР / AUTHOR(S): D. Dekanski 
, A. Rašković , N. Martić , A. Pirković , A. Jovanović
DOI: 10.46793/8FDSQ.PA2DD
САЖЕТАК / ABSTRACT:
The carob (Cerationa siliqua L.) pulp flour is used primarily in the food industry. As a valuable source of bioactive compounds (polyphenols), it is a good candidate for pharmaceutical formulation research and development. In this study, carob pulp extract-loaded liposomal particles were developed using the proliposome procedure and characterized via encapsulation efficiency (EE), vesicle size, polydispersity index (PDI), zeta potential, mobility, and viscosity. The obtained results suggest that the EE is high (80.6±3.3%). The particle size and PDI results indicated the existence of the multilamellar and uniform liposomal system. Lower values of zeta potential and mobility (-17.8±1.0 mV and -1.40±0.08 µmcm/Vs, respectively) of developed liposomes suggest that future experiments should be focused on the carob pulp liposomal nutraceutical formulation improvement, particularly its stability.
КЉУЧНЕ РЕЧИ / KEYWORDS:
ПРОЈЕКАТ/ ACKNOWLEDGEMENT:
This work was supported by the Ministry of Science, Technological Development and Innovation, Republic of Serbia (No. 451-03-66/2024-03/200019 and by the Provincial Secretariat for Higher Education and Scientific Research of Vojvodina (No. 142-451-3531/2023-01). The authors express gratitude to Z. Šereš, D. Šoronja-Simović, and J. Zahorec for extract preparation.
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