17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume II) (2024) [O-13-P, pp. 635-638]
AUTHOR(S) / AUTOR(I): Dragana Stanković 
, Magdalena Radović , Marija Mirković , Zorana Milanović , Aljoša Stanković , Milica Mijović , Miloš Ognjanović , Drina Janković , Aleksandar Vukadinović , Bratislav Antić , Sanja Vranješ-Đurić , Miroslav Savić and Željko Prijović
Download Full Pdf 
DOI: 10.46793/Phys.Chem24II.635S
ABSTRACT / SAŽETAK:
Combined radionuclide therapy with magnetic nanoparticles has been a research focus as a promising approach for tumor therapy. In this study, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized using the co-precipitation method and coated with meso-1,2- dimercaptosuccinic acid (DMSA). Structural investigations showed that DMSA-coated SPIONs had a particle size of 140.3±6.5 nm in diameter with a spherical morphology. With a zeta potential of −35.1 mV, functionalization with DMSA led to increase the stability of the nanoparticles in solution. DMSA-SPIONs were radiolabeled with 177Lu in high radiolabeling yield (86.6 ± 2.1%, and after separation by magnetic decantation >99%), showing high in vitro stability in saline and human serum up to 96 h. After intratumoral injection into mouse colorectal CT-26 or breast 4T1 subcutaneous tumors, the radiolabeled nanoparticles remained well localized at the injection site over a 14-day period, with limited leakage.
KEYWORDS / KLJUČNE REČI:
ACKNOWLEDGEMENT / PROJEKAT:
This work was supported by Centre of Excellence “VINCENT” funded by Ministry of Education, Science and Technological Development of the Republic of Serbia; the Ministry of Education, Science and Technological Development of Republic of Serbia (contract number: 451-03-47/2023- 01/200017); EU funded project FP7-EraChairs-MagBioVin (Grant agreement #621375) and COST Action CA 19114.
REFERENCES / LITERATURA:
- R. Siegel, K. Miller, N. Wagle, A. Jemal, CA Cancer J. Clin. 73(1) (2023) 17-48.
- Q. Liu, J. Zou, Z. Chen, W. He, W. Wu, Acta Pharmaceutica Sinica B, 13(11) (2023) 4391-4416.
- R. Massart, IEEE Trans. Magn. 17 (1981) 1247–1248.