17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume II) (2024) [O-09-P, pp. 619-622]
AUTHOR(S) / АУТОР(И): Marija Popović-Nikolić 
and Gordana Popović
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DOI: 10.46793/Phys.Chem24II.619PN
ABSTRACT / САЖЕТАК:
The protolytic equilibria of raloxifene were investigated in the presence of differently charged and/or polar micelles (CTAB, TX-100, Brij 35). The ionization constants were determined potentiometrically at a constant ionic strength (0.1 M NaCl) and temperature 25°C. In a relation to the pKa values previously determined in surfactant-free media, the presence of micelles caused a shift from -3.03 pKa to +3.12 pKa units. Significant changes in distribution of equilibrium forms at biopharmaceutically important pH values suggest on potential consideration of interactions between raloxifene and molecules present under the physiological conditions.
KEYWORDS / КЉУЧНЕ РЕЧИ:
ACKNOWLEDGEMENT / ПРОЈЕКАТ:
This research was funded by the Ministry of Science, Technological Development and Innovation, Republic of Serbia through two Grant Agreements with University of Belgrade-Faculty of Pharmacy No 451-03-65/2024-03/200161 and No 451-03-66/2024-03/ 200161. The authors thank the COST Actions CA18240, CA18133 and CA22125 of the European Community for support.
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