DEVELOPMENT OF Cu(II)-MESO-HMPAO COMPLEX AS A MODEL FOR POTENTIAL 64Cu RADIOPHARMACEUTICALS

17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume II) (2024) [M-04-P, pp. 569-572]  
      

AUTHOR(S) / АУТОР(И): Marija Mirković , Ferdinand Belaj , Marko Perić , Dalibor Stanković , Magdalena Radović , Zorana Milanović ,  Sanja Vranješ-Đurić , Drina Janković and Ljiljana E. Mihajlović-Lalić

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DOI: 10.46793/Phys.Chem24II.569M

ABSTRACT / САЖЕТАК:

Cu(II) complexes with meso-HMPAO and d,l-HMPAO were synthesized and characterized using single-crystal X-ray diffraction analysis, FTIR spectroscopy, cyclic voltammetry, and mass spectrometry. The electrochemical data indicated that the complexes bind to DNA molecules, specifically through guanine. These findings suggest that the new compounds have significant potential for further investigation, particularly for their anticancer activity and as models for the development of radiopharmaceuticals with 64Cu.

KEYWORDS / КЉУЧНЕ РЕЧИ:

ACKNOWLEDGEMENT / ПРОЈЕКАТ:

The research was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia, contract numbers: 451-03-66/2024-03/200017, 451-03-47/2023- 01/200288; VINCENT Center of Excellence; and Science fund of the Republic of Serbia, Program PRIZMA, GRANT No 4961/2023, Project title RADIOMAG.

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