EFFECTS OF Phytolacca dioica EXTRACT ON IONIZING RADIATION-INDUCED DAMAGE IN VITRO

8th WORKSHOP: FOOD AND DRUG SAFETY AND QUALITY, (pp.151–155)

 

АУТОР / AUTHOR(S): S. Petrović , B. Laban , T. Momić , A. Leskovac

Download Full Pdf  

DOI: 10.46793/8FDSQ.PC5SP

САЖЕТАК / ABSTRACT:

This pilot study aimed to examine the impact of Phytolacca dioica on ionizing radiation-induced DNA damage and lipid peroxidation using human peripheral blood lymphocytes as a model system. The results showed that P. dioica possesses neither antioxidant nor genoprotective effects in radiolytically damaged tissue. Its potential use as a radiosensitizer should be further examined.

КЉУЧНЕ РЕЧИ / KEYWORDS:

ПРОЈЕКАТ / ACKNOWLEDGEMENT:

This work was supported by the Ministry of Science, Technological Development and Innovation of the Republic of Serbia (Grant no. 451-03-66/2024-03/200017).

ЛИТЕРАТУРА / REFERENCES: 

[1] Y.  Zhang, Y. Huang, Z. Li, H. Wu, B. Zou, Y. Xu, Cancers (Basel), 2023, 15, 3585.

[2] A. Di Petrillo, A. María González-Paramás, A. Rosa, V. Ruggiero, F. Boylan, A. Kumar, F. Pintus, C. Santos-Buelga, A. Fais, B. Era, J. Enzyme Inhib. Med. Chem., 2019, 34, 519-527.

[3] M. Srivastava, D. Chandra, R. K. Kale, Radiat Res, 2002, 157, 290-297.

[4] M. Raeispour, F. Talebpour Amiri, S. Farzipour, A. Ghasemi, S.J. Hosseinimehr, Drug Chem. Toxicol., 2022, 45, 2586-2593.

[5] Law on Health Care Official Gazette of the Republic of Serbia, no. 25/2019.

[6] OECD, Test No. 487: In Vitro Mammalian Cell Micronucleus Test. 2023

[7] M. Fenech, Mutat. Res., 1993, 285, 35-44.

[8] J. Surralles, N. Xamena, A. Creus, R. Marcos, Mutat Res., 1995, 342, 43-59.

[9] O. I. Aruoma et al., Biochem. J., 1989, 258, 617-620.