Quality assessment of quinine sulfate samples in 19th and early 20th centuries in Portugal: the role of the Lusitanian Pharmaceutical Society

46th International Congress for the History of Pharmacy (2024) (стр. 155-160)

 

АУТОР / AUTHOR(S): Maria Guilherme Semedo , João Rui Pita , Ana Leonor Pereira

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DOI: 10.46793/ISHP46.155S

САЖЕТАК / ABSTRACT:

Cinchona bark-derived medicines such as quinine sulfate were the only effective and widely used antimalarial treatments until the mid-twentieth century. The aim of this communication is to find and discuss references to quality control of quinine sulfate samples in a Portuguese pharmaceutical journal. For this purpose, we analyzed the Jornal da Sociedade Pharmaceutica Lusitana (Journal of the Lusitanian Pharmaceutical Society). This was an important Portuguese journal, edited by the Lusitanian Pharmaceutical Society, a pharmacist’s organization (1838-1933). This journal reflects Portuguese pharmacy’s evolution, and the professional and scientific issues faced by pharmacists in Portugal.
We located 10 chemical analyses of quinine sulfate samples in the Jornal da Sociedade Pharmaceutica Lusitana. These were performed in 1838, 1847, 1868, 1881, 1890, 1891, 1893, 1897 and 1907 by members of the Lusitanian Pharmaceutical Society. These analyses meant to control the quality of the quinine sulfate samples, namely in terms of chemical purity. The analyses performed in 1838, 1881, 1891, 1893, 1897 and 1907 assessed samples from a single provenance. The other analyses were comparative studies between samples of different origins and were performed in 1847, 1868 and 1890.
One of the samples (analyzed in 1838 and 1847) was made by a member of the Society, José Cardoso, who was a pharmacist in a Portuguese city called Mirandela. The other samples were produced by commercial companies based in different countries: France, Great Britain, Italy, Germany, and Portugal. The French samples came from the Pelletier, Delondre and Levaillant company (analyzed in 1847 and 1868); the Howards and Sons samples were British (analyzed in 1868 and 1890); a factory in Milan provided the Italian samples (1881); the German samples came from Conrad Zimmer’s company (1868), Boehringer & Söhne (1890, 1893) and Braunschweig factory (1891); and the Portuguese enterprises Sociedade Luso-Africana (1893, 1897) and Laboratorio Chimico-pharmaceutico (1907) provided the Portuguese samples. Most of the analyses were commissioned by parties external to the society.
All analyzed samples were considered pure, namely according to parameters of the French and/ or Portuguese pharmacopoeias. The reports on the quinine sulfate analyses describe the tests’ results regarding the samples’ quality. In some of these analyses the authors also stress the suitability of the samples for medical or therapeutical uses in view of the results they obtained. These analyses reflect the importance attributed to chemical purity, and the problem of medicines’ adulteration and falsification. The falsification of quinine sulfate (and other medicines) was highlighted in this pharmaceutical journal, featuring methods for the detection of those falsifications, as well as reports on counterfeit medicines found in Portugal. The Lusitanian Pharmaceutical Society was therefore involved in quinine sulfate’s quality control in Portugal.

КЉУЧНЕ РЕЧИ / KEYWORDS:

quinine; Portugal; history of pharmacy; 19th century; 20th century

ПРОЈЕКАТ / ACKNOWLEDGEMENTS:

This work is funded by national funds through the FCT – Fundaçã o para a Ciência e a Tecnologia, I.P., in the scope of the project UIDB/00460/2020.

ЛИТЕРАТУРА / REFERENCES:

  1. Alves, Joaquim José, Fragoso, Emilio (1893). Parecer da commissão de chimica sobre uma amostra de sulfato de quinina. Jornal da Sociedade Pharmaceutica Lusitana, 4, 90–91.
  2. Alves, Joaquim José, Machado, Alfredo da Silva, Fragoso, Emilio (1893) Parecer da commissão de chimica sobre uma analyse de sulfato de quinina,
    approvado em sessão de 21 de março de 1893. Jornal da Sociedade Pharmaceutica Lusitana. 4, 113–114
  3. Cabral, B. J. O. T. (1834) Pharmacopea Das Pharmacopeas Nacionaes e Estrangeiras, Excepto a Geral Destes Reinos, Citadas Nos Regimentos Dos
    Pharmaceuticos Portuguezes de 1831, 1833, e 1834: Ou Collecção de Todas as Formulas e Processos Dos Medicamentos Preparados Conforme as pharmacopeas Bateana, de Baumé, de Chevallier, de Dublin, d’Edimburgo,
    Franceza, de Fuller, Hespanhola, Herbipolitana, de Lewis, de Londres, Lusitana, de Palacios, de Parmentier, Suecica, de Swediaur, Tubalense, de Van Mons, de Virey, e Wittenbergica: conforme as Pharmacologias Chirurgicas, de Londres, e de Plenck: conforme os Dispensatorios d’Edimburgo, e de Fulda:
    conforme os Formularios Magistraes de Cadêt, e de Magendie: e conforme Boerhaave, Bodard, Baglivio, Darwin, Goulard, Henry (filho), Rego, Thenard, Tissot, e Van-Swieten: e tambem Das Formulas e Processos dos Medicamentos, cujas Preparações os Regimentos sobreditos não citão em Pharmacopéa alguma, nem se achão na Geral destes Reinos: incluidos outros Additamentos importantes, e a designação das Virtudes e Doses dos Medicamentos, autorisada com a citação dos Praticos mais acreditados. Acompanhada d’estampas e taboas muito uteis (Vol. 2). Lisboa: Imprensa Nacional.
  4. Carvalho, Francisco de (1890a) Sessão de 11 de Novembro de 1890. Jornal da Sociedade Pharmaceutica Lusitana. 1, 215-220.
  5. Carvalho, Francisco de (1890b). Sessão de 26 de Março de 1890. Jornal da Sociedade Pharmaceutica Lusitana. 1, 64-69.
  6. Carvalho, Francisco de (1891). Sessão de 13 de Janeiro de 1891. Jornal da Sociedade Pharmaceutica Lusitana. 2, 21-26
  7. Correia, José Dionysio, Veiga, Joaquim Urbano da, Ferreira, Antonio Augusto Felix (1868). Consulta da Sociedade Pharmaceutica Lusitana ácerca do sulphato de quinina preparado pelo Sr. Conrade Zimmer de Francfort. Jornal da Sociedade Pharmaceutica Lusitana. 4, 196-199.
  8. Double F.J. (1820). Considérations thérapeutiques sur une nouvelle préparation de quinquina. Revue médicale. 6:130–152.
  9. Fonseca, Antonio Carvalho da [et al.] (1907). Parecer da Commissão de Chimica sobre uma amostra de sulfato de quinina, nacional. Jornal da Sociedade Pharmaceutica Lusitana. 3, 41–42.
  10. Fragoso, Emilio (1891). Sessão de 10 de Março de 1891. Jornal da Sociedade Pharmaceutica Lusitana. 2, 85-88.
  11. Freire, C. M. M. (1848-1849). Acta n.º 316, de 25 de Junho de 1847. Jornal da Sociedade Pharmaceutica Lusitana. 5 (4), 98–100.
  12. Gomes, Bernardino Antonio [et al.] (1876). Pharmacopêa portugueza. Edição official. Lisboa: Imprensa Nacional.
  13. Institute of Medicine (2013). Countering the Problem of Falsified and Substandard Drugs. Washington, DC: The National Academies Press.
    https://doi.org/10.17226/18272.
  14. Junior, F. M. C. Leal (1838). Parecer e analyse sobre o Sulphato de Quinina, preparado e remettido pelo Membro Correspondente Nacional, o Sr. JOSÉ ANTONIO SILVERIO RODRIGUES CARDOSO, Pharmaceutico em Mirandella; e approvada pela Sociedade, em Sessão Litteraria de 10 de Junho de 1838. Jornal da Sociedade Pharmaceutica Lusitana. 2 (1), 78–79.
  15. Pelletier, Caventou (1820). Recherches chimiques sur le Quinquinas. Annales de Chimie et de Physique. 15, 289–318; 337–365.
  16. Seiça, Vicente José de (1897). Analyse do sulfato de quinina da Sociedade Luso-Africana feita no Dispensatorio Pharmaceutico dos Hospitaes da Universidade. Jornal da Sociedade Pharmaceutica Lusitana. 3, 167–168.
  17. Semedo, Maria Guilherme, Pereira, Ana Leonor, Pita, João Rui (2023) Investigação científica e uso clínico da quina em Portugal na transição do
    século XVIII para o século XIX. Dynamis. 43 (2), 505-531.
  18. Semedo, Maria Guilherme Canivete (2023). A quina e a quinina na literatura farmacêutica portuguesa (séculos XVIII-XX) [Cinchona bark and quinine in
    the Portuguese pharmaceutical and medical literature (18th-20th centuries)] (Unpublished PhD thesis). Faculty of Pharmacy, University of Coimbra, Portugal.
  19. Sherman, Irwin W. (2011). Magic Bullets to Conquer Malaria: From Quinine to Qinghaosu. Washington, DC: ASM Press.
  20. Telles, João José de Sousa, Machado, Alfredo da Silva, Mattos, Josè Gomes de (1881). Consulta da sociedade pharmaceutica lusitana ácerca de uma amostra de sulfato de quinina que lhe foi enviada pelos srs. Creswell & C.a, representantes em Lisboa da fabrica lombarda de productos chimicos em Milão. Jornal da Sociedade Pharmaceutica Lusitana. 2, 189.
  21. Webb Jr., James L. A. (2009). Humanity’s Burden. A Global History of Malaria. Cambridge: Cambridge University Press.