ETHNOPHARMACOLOGY OF DIABETES: FROM TRADITIONAL RECIPES TO MODERN MEDICINE

58. KONGRES ANTROPOLOŠKOG DRUŠTVA SRBIJE (ADS 2025), [pp. 34-41]

AUTHOR(S) / АУТОР(И):  Višnja Madić , Aleksandra Petrović , Perica Vasiljević

Download Full Pdf   

DOI: 10.46793/ADS25.34M

ABSTRACT / САЖЕТАК:

Diabetes is one of the most prevalent chronic diseases of the 21st century. Current pharmacological interventions used in the management of this condition regulate hyperglycemia; however, they do not fully prevent the onset or progression of its secondary complications, including diabetic nephropathy, hepatic dysfunction, osteoporosis, neuropathy, retinopathy, cardiovascular diseases, increased risk of dementia, etc. Consequently, a growing number of individuals with diabetes, in addition to conventional pharmacotherapy, are incorporating herbal alternatives derived from traditional medicine, particularly in the form of herbal mixtures, which are believed to enhance therapeutic outcomes in the management of multifactorial diseases such as diabetes. Given that medicinal plants, and especially herbal mixtures, consist of a diverse array of bioactive compounds that may exert synergistic, additive, or antagonistic effects, it is plausible that their concomitant use with standard pharmaceutical agents could offer benefits in terms of glycemic control, attenuation of secondary complications, and mitigation of pharmacological side effects. However, this practice may also pose risks, including the potential for hypoglycemia, hepatotoxicity, nephrotoxicity, and other adverse effects. Therefore, comprehensive investigations into biological activities and their mechanisms of actions of both individual herbs and their combinations, particularly when used as adjuncts to conventional therapies, are imperative for ensuring their safety and efficacy in the treatment of diabetes and its associated complications.

KEYWORDS / КЉУЧНЕ РЕЧИ:

Traditional medicine; Pharmacology; Diabetes

ACKNOWLEDGEMENT / ПРОЈЕКАТ:

This work was supported by the Ministry of Science, Technological Development and Innovation of the Republic of Serbia (Grant No. 451-03-137/2025-03/200124 and 451-03-136/2025-03/200124).

REFERENCES / ЛИТЕРАТУРА:

  • Arvanitakis, Z., Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004). Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Archives of neurology61(5), 661-666.
  • Auten, A. A., Beauchamp, L. N., Taylor, J., & Hardinger, K. L. (2013). Hidden sources of grapefruit in beverages: potential interactions with immunosuppressant medications. Hospital Pharmacy48(6), 489-493.
  • Bailey, C. J. (2017). Metformin: historical overview. Diabetologia, 60(9), 1566-1576.
  • Bastaki, S. (2005). Diabetes mellitus and its treatment. International Journal of Diabetes and Metabolism13(3), 111-134.
  • Bera, T. K., De, D., Chatterjee, K., Ali, K. M., & Ghosh, D. (2010). Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats. International Journal of Ayurveda Research1(1), 18.
  • Campbell, I. W. (2001). Type 2 diabetes mellitus:‘the silent killer’. Practical Diabetes International, 18(6), 187-191.
  • Damnjanovic, I., Kitic, D., Stefanovic, N., Zlatkovic-Guberinic, S., Catic-Djordjevic, A., & Velickovic-Radovanovic, R. (2015). Herbal self-medication use in patients with diabetes mellitus type 2. Turkish journal of medical sciences45(4), 964-971.
  • Đorđević, M., Grdović, N., Mihailović, M., Jovanović, J. A., Uskoković, A., Rajić, J., … & Dinić, S. (2019). Centaurium erythraea extract improves survival and functionality of pancreatic beta-cells in diabetes through multiple routes of action. Journal of Ethnopharmacology242, 112043.
  • Dziewa, M., Bańka, B., Herbet, M., & Piątkowska-Chmiel, I. (2023). Eating disorders and diabetes: Facing the dual challenge. Nutrients15(18), 3955.
  • Engerman, R. L. (1989). Pathogenesis of diabetic retinopathy. Diabetes38(10), 1203-1206.
  • Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002). Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocrine reviews23(5), 599-622.
  • FDA. U.S. Food and Drug Administration (2015). SGLT2 inhibitors: Drug Safety Communication – FDA Warns Medicines May Result in a Serious Condition of Too Much Acid in the Blood.
  • Feldman, Eva L., Brian C. Callaghan, Rodica Pop-Busui, Douglas W. Zochodne, Douglas E. Wright, David L. Bennett, Vera Bril, James W. Russell, and Vijay Viswanathan. „Diabetic neuropathy.“ Nature reviews Disease primers 5, no. 1 (2019): 41.
  • Gross, J. L., De Azevedo, M. J., Silveiro, S. P., Canani, L. H., Caramori, M. L., & Zelmanovitz, T. (2005). Diabetic nephropathy: diagnosis, prevention, and treatment. Diabetes care28(1), 164-176.
  • Guven, A., Yavuz, O., Cam, M., Ercan, F., Bukan, N., Comunoglu, C., & Gokce, F. (2006). Effects of melatonin on streptozotocin-induced diabetic liver injury in rats. Acta histochemica, 108(2), 85-93.
  • Han, X., Yang, Y., Metwaly, A. M., Xue, Y., Shi, Y., & Dou, D. (2019). The Chinese herbal formulae (Yitangkang) exerts an antidiabetic effect through the regulation of substance metabolism and energy metabolism in type 2 diabetic rats. Journal of ethnopharmacology239, 111942.
  • Heinrich, M. (2015). Quality and safety of herbal medical products: regulation and the need for quality assurance along the value chains. British Journal of Clinical Pharmacology80(1), 62-66.
  • Institute of Public Health ‘Dr. Milan Jovanovic Batut’ (2021). Available from: https://batut.org.rs/index.php?content=187
  • International Diabetes Federation. IDF Diabetes Atlas, 10th edn. Brussels, Belgium: International Diabetes Federation, 2021.
  • Inzucchi, S. E., Bergenstal, R. M., Buse, J. B., Diamant, M., Ferrannini, E., Nauck, M., … & Matthews, D. R. (2015). Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes care38(1), 140-149.
  • Kararli, T. T. (1995). Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharmaceutics & drug disposition16(5), 351-380.
  • Kirpichnikov, D., McFarlane, S. I., & Sowers, J. R. (2002). Metformin: an update. Annals of internal medicine, 137(1), 25-33.
  • Luo, Y., Zeng, Y., Peng, J., Zhang, K., Wang, L., Feng, T., … & Fan, G. (2023). Phytochemicals for the treatment of metabolic diseases: Evidence from clinical studies. Biomedicine & Pharmacotherapy165, 115274.
  • Madić, V., Petrović, A., Jugović, D., Maksimović, B., & Vasiljević, P. (2023). Life with diabetes in the COVID-19 era. Glasnik Antropološkog društva Srbije. 56(1-2):41-7.
  • Madić, V., Petrović, A., Jušković, M., Jugović, D., Djordjević, L., Stojanović, G., & Vasiljević, P. (2021). Polyherbal mixture ameliorates hyperglycemia, hyperlipidemia and histopathological changes of pancreas, kidney and liver in a rat model of type 1 diabetes. Journal of Ethnopharmacology265, 113210.
  • Madić, V., Petrović, A., Maksimović, B., Đorđević, Lj., Vasiljević, P. (2022). Uticaj insulina glargina na regulaciju oštećenja pankreasa u aloksanom indukovanom modelu dijabetesa. Treći kongres biologa Srbije, 360.
  • Madić, V., Petrović, A., Žabar Popović, A., Maksimović B., Jušković, M., Vasiljević, P. (2022). Biological activity of ‘anti-diabetic’ herbal mixture and five medicinal plants methanolic and ethanolic extracts. 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 189.
  • Madić, V., Popović, A. Ž., Vukelić-Nikolić, M., Đorđević, L., & Vasiljević, P. (2018). Ethnopharmacological therapies in the treatment of diabetes in Serbia. Glasnik Antropološkog društva Srbije53(1-2).
  • Madić, V., Stojanović-Radić, Z., Jušković, M., Jugović, D., Popović, A. Ž., & Vasiljević, P. (2019). Genotoxic and antigenotoxic potential of herbal mixture and five medicinal plants used in ethnopharmacology. South African Journal of Botany125, 290-297.
  • Mahajan, N. M., Lokhande, B. B., Thenge, R. R., Gangane, P. S., & Dumore, N. G. (2018). Polyherbal formulation containing antioxidants may serve as a prophylactic measure to diabetic cataract: Preclinical investigations in rat model. Pharmacognosy Magazine14(58).
  • Manna, P., Das, J., Ghosh, J., & Sil, P. C. (2010). Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid. Free Radical Biology and Medicine48(11), 1465-1484.
  • Mirmiran, P., Bahadoran, Z., & Azizi, F. (2014). Functional foods-based diet as a novel dietary approach for management of type 2 diabetes and its complications: A review. World journal of diabetes, 5(3), 267.
  • Ott, A., Stolk, R. P., Van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999). Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology53(9), 1937-1937.
  • Panten, U., Schwanstecher, M., & Schwanstecher, C. (1996). Sulfonylurea receptors and mechanism of sulfonylurea action. Experimental and clinical endocrinology & diabetes104(01), 1-9.
  • Paolini, M., Cantelli-Forti, G., Perocco, P., Pedulli, G. F., Abdel-Rahman, S. Z., & Legator, M. S. (1999). Co-carcinogenic effect of β-carotene. Nature398(6730), 760-761.
  • Parasuraman, S., Thing, G. S., & Dhanaraj, S. A. (2014). Polyherbal formulation: Concept of ayurveda. Pharmacognosy reviews8(16), 73.
  • Petrović, A., Madić, V., Jušković, M., Đorđević, L., & Vasiljević, P. (2021). Osteoprotective effects of’anti-diabetic’polyherbal mixture in type 1 diabetic rats. Acta Veterinaria71(3).
  • Petrović, A., Madić, V., Stojanović, G., Zlatanović, I., Zlatković, B., Vasiljević, P., & Đorđević, L. (2024). Antidiabetic effects of polyherbal mixture made of Centaurium erythraea, Cichorium intybus and Potentilla erecta. Journal of Ethnopharmacology319, 117032.
  • Petrović, A., Stojković, K., Madić, V., & Đorđević, L. (2022). In vitro antioxidant and antidiabetic potential of herbal mixture traditionally used in treatment of diabetes mellitus. Biologica Nyssana13(2).
  • Piantadosi, S. (2024). Clinical trials: a methodologic perspective. John Wiley & Sons.
  • Russell‐Jones, D., & Khan, R. (2007). Insulin‐associated weight gain in diabetes–causes, effects and coping strategies. Diabetes, Obesity and Metabolism9(6), 799-812.
  • Savage, D. B., Petersen, K. F., & Shulman, G. I. (2007). Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiological reviews87(2), 507-520.
  • Schloot, N. C., Haupt, A., Schütt, M., Badenhoop, K., Laimer, M., Nicolay, C., … & German/Austrian DPV Initiative. (2016). Risk of severe hypoglycemia in sulfonylurea‐treated patients from diabetes centers in Germany/Austria: How big is the problem? Which patients are at risk?. Diabetes/metabolism research and reviews, 32(3), 316-324.
  • Sneader, W. (2000). The discovery of aspirin: a reappraisal. Bmj321(7276), 1591-1594.
  • Uchida, S., Yamada, H., Li, X. D., Maruyama, S., Ohmori, Y., Oki, T., … & Yamada, S. (2006). Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers. The Journal of Clinical Pharmacology46(11), 1290-1298.
  • Umamaheswari, S., Prathiba, D., Srikanth, J., & Reddy, U. (2009). Antioxidant potential of a polyherbal formulation (Diabet) on alloxan induced oxidative stress in rats. Drug Invention Today1(1).
  • Volpe, C. M. O., Villar-Delfino, P. H., Dos Anjos, P. M. F., & Nogueira-Machado, J. A. (2018). Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell death & disease9(2), 119.