VITAMIN E AND SELENIUM IN THE PREVENTION OF NUTRITIONAL MUSCULAR DYSTROPHY IN LAMBS

4th International Symposium On Biotechnology (2026),  [pp. 455-463]
 
AUTHOR(S) / AUTOR(I): Vladimir Dosković , Milica Metlić, Snežana Bogosavljević-Bošković , Milun D. Petrović , Simeon Rakonjac , Bojan Stojanović 
 
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DOI: https://doi.org/10.46793/SBT26.455D

ABSTRACT / SAŽETAK:

The study investigates nutritional muscular dystrophy in lambs and the impact of selenium and vitamin E supplementation in their diet on the occurrence and prevention of this disease. Vitamin E and selenium play crucial roles in the animal body in relation to growth and development, reproduction, production performance, health status, and immunity. The physiological importance of selenium and vitamin E for living organisms is based on their strong antioxidant activity.

Nutritional muscular dystrophy, also known as white muscle disease (myopathy, NMD), frequently occurs in lambs and older categories of sheep as a result of selenium and/or vitamin E deficiency in the diet. This deficiency, together with a high intake of unsaturated fatty acids, increases the concentration of peroxides in the body. The consequence is degeneration of skeletal and cardiac muscles. Increased serum concentrations of the enzymes aspartate aminotransferase, lactate dehydrogenase, and creatine kinase, along with low selenium and vitamin E levels and reduced glutathione peroxidase activity, are the most reliable indicators of nutritional muscular dystrophy in lambs.

KEYWORDS / KLJUČNE REČI:

nutritional muscular dystrophy, lambs, selenium, vitamin E

ACKNOWLEDGEMENT / PROJEKAT:

The research presented in this article is part of No. 451-03-33/2026-03/ 200088 financially supported by Ministry of Science, Technological Development and Innovation of Republic of Serbia.

REFERENCES / LITERATURA:

  • Abood H.K., Judi A.M.H., Al-Ani A.A. (2012). The effect of experimentally induced vitamin E and selenium deficiency on Creatine Kinase (CK) and Aspartate Aminotransferase (AST) activities in Awassi ewes and their newborn lambs. Kufa Journal For Veterinary Medical Sciences, 3 (1), 132-137.
  • Bayomi Y.H., Mohamed W.A.M., Morsi A.K.M. (2017). Oxidative stress biomarkers in dystrophic lambs and kids in relation to body condition scores. Zagazig Veterinary Journal, 45 (S1), 189-200.
  • Błażejak-Grabowska J., Milewski S., Ząbek K., Sobiech P.H., Wόjcik R.M., Żarczyńska K., Miciński J. (2022). Effect of longacting selenium preparation on health and productivity of sheep. Animals, Multidisciplinary Digital Publishing Institute, 12 (2), 140.
  • Değer Y., Mert H., Mert N., Yur F., Kozat S., Yörük I.H., Sel T. (2008). Serum selenium, vitamin E and sialic acids concentrations in lambs with white muscle disease. Biological Trace Element Research 121, 39-43.
  • Delesalle C., De Bruijn M., Wilmink S., Vandendriessche H., Mol G., Boshuizen B., Plancke L., Grinwis G. (2017). White muscle disease in foals: focus on selenium soil content. A case series. BMC Veterinary Research, 13, 121.
  • Duncan J.R., Prasse K.W. (1986). Veterinary laboratory medicine, clinical pathology. Second edition, Iowa, State University Press, Ames, 285.
  • El-Deeb W.M. (2010). Ascorbate-glutathion affiliation and the treatment of nutritional muscular dystrophy in lambs with special reference to the oxidative stress. Cercetgri Agronomice ĭn Moldova XLIII, (2), 77-86.
  • El-Neweehy T.K., Abdel-Rahman H.A.R., Al-Qarawi A.A. (2001). Some studies on nutritional muscular dystrophy in Qassim region in Saudi Arabia. Effect of administration of vitamin E-selenium preparation to pregnant ewes on serum muscle-specific enzymes in their lambs. Small Ruminant Research, 41 (1), 87-89.
  • Fancote C.R., Vercoe P.E., Pearce K.L., Williams I.H., Norman H.C. (2013). Backgrounding lambs on saltbush provides an effective source of Vitamin E that can prevent Vitamin E deficiency and reduce the incidence of subclinical nutritional myopathy during summer and autumn. Animal Production Science, 53 (3), 247-255.
  • Ghanem M.M., Anwar M.R., Abd El-Raof Y.M., El-Attar H.M. (2016). Clinical, hematological and biochemical changes in lambs suffered from nutritional muscular dystrophy. Behna Veterinary Medical Journal, 30 (2), 61-66.
  • Kohli R., Harris D.C., Whitington P.F. (2005). Relative elevation of serum alanine and aspartate aminotransferasee in muscular dystrophy. Journal of Pediatric Gastroenterology and Nutrition, 41 (1), 121-124.
  • Mc Murray C.H., Mc Eldowlney P.K. (1977). A possible prophylaxis and model for nutritional degenerative myopathy in young cattle. British Veterinary Journal, 133, 535-542.
  • Mehdi Y., Dufrasne I. (2016). Selenium in Cattle. A Review Molecules, 21, 545.
  • Qin S., Gao J., Huang K. (2007). Effects of different selenium sources on tissue selenium concentrations, blood GSH-Px activities and plasma interleukin levels in finishing lambs. Biological Trace Element Research, 116, 91-102.
  • Ramírez-Bribiesca E., Hernández-Camacho E., Hernandez-Calva L.M., Tórtora-Pérez J.L. (2004). Effect of parenteral supplement with sodium selenite on lamb mortality and hematic values of selenium. Agrociencia 38 (1), 43-51.
  • Ružić-Muslić D., Petrović M.P., Caro-Petrović V., Petrović M.M., Bjelić Z., Ilić Z., Stojković J. (2014). Effects of adding different forms of selenium in diets for fattening lambs. Biotechnology in Animal Husbandry 30 (4), 589-600.
  • Serratos M.J.H., Ramirez M.J., Farina I.G., Perez J.L.T., Trujillo E.H., Sanchez V.M.D. (2024). Description of lesions in lambs intoxicated with sodium selenite included in intraruminal boluses, lambs intoxicated with selenium. Veterinary Medicine and Science, 10 (5), 1584.
  • Slupczyńska M., Kinal S., Król B. (2009). Utilization of selenium compounds in nutrition of lambs. Journal o Elementology, 14 (1), 159-161.
  • Suttle N.F. (2010). Mineral Nutrition of Livestock (4th edition). CAB International.
  • Tiwary A.K., Stegelmeier B.L., Panter K.E., James L.F., Hall J.O. (2006). Comparative toxicosis of sodium selenite and selenomethionine in lambs. Journal of Veterinary Diagnostic Investigation, 18 (1), 61-70.
  • Yanuartono Y., Indarjulianto S., Paryuni A. D. (2024). The role of selenium and vitamin E in ruminants. Jurnal Ilmiah Ilmu-Ilmu Peternakan, 27 (1), 9-37.
  • Yildirim S., Irak K., Mert H., Dogan I., Mert N. (2016). Serum biochemical and histopathological examinations of some tissues of lambs with muscular dystrophy in van. Veterinary Medicine, 2, 52-55.
  • Żarczyńska K., Babińska I., Snarska A., Sobiech P. (2019). Levels of selenium and vitamin E in the blood and morphological changes in the biceps femoris muscle during nutritional muscular dystrophy of calves. Journal of Elementology, 24 (4), 1363-1370.
  • Żarczyńska K., Baumgartner W., Sobiech P. (2017). Coagulology, biochemical profile and muscle pathology in calves diagnosed with nutritional muscular dystrophy. Polish Journal of Veterinary Sciences, 20 (2), 387-394.