CARDIOPROTECTIVE EFFECTS OF LADY’S BEDSTRAW EXTRACT: FOCUS ON OXIDATIVE STRESS

2nd International Symposium On Biotechnology (2024),  [565-570]

AUTHOR(S) / АУТОР(И): Anica Petrović, Jovana Bradić, Marijana Andjić, Aleksandar Kočović, Jovana Novaković, Vladimir Jakovljević

E-MAIL: 

Download Full Pdf   

DOI: 10.46793/SBT29.75AP

ABSTRACT / САЖЕТАК:

Beside the widespread traditional use of Lady’s Bedstraw in the treatment of numerous diseases and conditions, itʼs effects on heart function and redox status has still not been fully clarified. The aim of our study was to examine the effects of methanol extract of Lady’s Bedstraw on oxidative stress parameters during on ischemia-reperfusion (I/R) injury in isolated rat heart. Our results demonstrated that treatment with methanol extract of Lady’s Bedstraw preserved diminished production of many prooxidants. Promising potential of Lady’s Bedstraw in the present study in a model of pharmacological preconditioning may be a starting point for future researches.

KEYWORDS / КЉУЧНЕ РЕЧИ:

Lady’s Bedstraw, ischemia-reperfusion injury, oxidative stress, rat heart

REFERENCES / ЛИТЕРАТУРА:

  • Xia Z., Li H., Irwin M.G. (2016). Myocardial ischaemia reperfusion injury: the challenge of translating ischaemic and anaesthetic protection from animal models to humans. British journal of anaesthesia. 117: ii44–ii62
  • Kalogeris T., et al. (2016). Ischemia/reperfusion. Comprehensive physiology, 7 (1): 113–170.
  • Li W. et al. (2015). Pharmacological preconditioning and postconditioning with nicorandil attenuates ischemia/reperfusion-induced myocardial necrosis and apoptosis in hypercholesterolemic rats. Experimental and therapeutic medicine. 10 (6): 2197–2205.
  • Bartekova, M. et al. (2010). Acute treatment with polyphenol quercetin improves postischemic recovery of isolated perfused rat hearts after global ischemia. Canadian Journal of Physiology and Pharmacology. 88 (4): 465–471.
  • Lakiic N. et al. (2010). Antioxidant properties of Galium verum L. (Rubiaceae) extracts. Central European journal of biology. 5: 331–337.
  • Vlase L., Mocan A., Hanganu D. (2014). Comparative study of polyphenolic content, antioxidant and antimicrobial activity of four Galium species (Rubiaceae). Digest journal of nanomaterials and biostructures. 9: 1085–1094.
  • Bradic J., et al. (2019). Protective Effects of Galium verum L. Extract against Cardiac Ischemia/Reperfusion Injury in Spontaneously Hypertensive Rats. Oxidative medicine and cellular longevity. 2019: 4235405.
  • Mattera R. et al. (2017). Effects of polyphenols on oxidative stress-mediated injury in cardiomyocytes. Nutrients. 9 (5).
  • Debnath J., Nath K. (2014). A review on pathophysiology of ischemic-reperfusion injury of heart and ameliorating role of flavonoids and polyphenols. Journal of medicinal plants research. 8: 607–614.