2nd International Symposium On Biotechnology (2024), [531-536]
AUTHOR(S) / АУТОР(И): Ana Obradović, Milena Vukić, Milica Paunović, Branka Ognjanović, Nenad Vuković, Miroslava Kačániová, Miloš Matić
E-MAIL: ana.obradovic@pmf.kg.ac.rs
DOI: 10.46793/SBT29.71AO
ABSTRACT / САЖЕТАК:
The aim of this study was to investigate antitumor capacity of different Tanacetum balsamita essential oils by measuring apoptosis rate, MMP-9 concetration and Nrf-2 expression level in human MBA-MB-468 and MDA-MB-231 cells. The tested EOs expressed proapoptotic effects, significantly inhibited the MMP-9 concentration and down-regulated the expression level of Nrf-2. The obtained data suggest that the tested EOs exert considerable antitumor activity elevating apoptosis level and inhibiting the motility of tested cancer cells. The reduced levels of Nrf-2 expression suggest decreased defense potential for oxidative disturbances, which could be the major antitumor mechanism detected in the study.
KEYWORDS / КЉУЧНЕ РЕЧИ:
Tanacetum balsamita essential oils, breast cancer cell lines, Nrf-2, MMP-9, apoptosis rate
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