AUTHOR(S) / АУТОР(И): Goran Petrović, Aleksandra Đorđević, Jelena Stamenković, Marija Dimitrijević, Jelena Nikolić, Vesna Stankov Jovanović, Violeta Mitić
E-MAIL: peca@pmf.ni.ac.rs
DOI: 10.46793/SBT29.60GP
ABSTRACT / САЖЕТАК:
Geranium macrorrhizum L., commonly known as “Zdravac” is an herbaceous medicinal plant that is traditionally used to treat skin diseases such as cuts, burns, and eczema. The essential oil obtained from the aerial parts of the plant is widely used in ethnopharmacology, perfumery and cosmetics. Germacrone is a bioactive natural compound found as part of the essential oils of different plants that are widely distributed throughout the world. This multifaceted chemical entity has become a point of focus during recent years due to its numerous pharmacological applications. The aim of the present study was to determine the chemical composition of the essential oil obtained from aerial parts of Geranium macrorrhizum and to develop the new method of pure germacrone isolation as its main component.
KEYWORDS / КЉУЧНЕ РЕЧИ:
REFERENCES / ЛИТЕРАТУРА:
- Ahmadi L., Mirza M. (2001). Volatile constituents of Dracocephalum aucheri Boiss. Journal of Essential Oil Research, 13, 202-203.
- Carlton R.R., Waterman P.G., Gray A.I. (1992). The antifungal activity of the leaf gland volatile oil of sweet gale (Myrica gale). Chemoecology, 3, 45-54.
- Chalchat J., Petrovic S.D., Maksimovic Z.A., Gorunovic M.S. (2002). A comparative study on essential oils of Geranium macrorrhizum L. and Geranium phaeum L., Geraniaceae from Serbia. Journal of Essential Oil Research, 14, 333-335.
- Doss R.P., Luthi R., Hrutfiord B.F. (1980). Germacrone, a sesquiterpene repellent to obscure root weevil from Rhododendron edgeworthii. Phytochemistry, 19, 2379-2380.
- Doss R.P., Hatheway W.H., Hrutfiord B.F. (1986). Composition of essential oils of some lipidote Rhododendrons. Phytochemistry, 25, 1637-1640.
- Morikawa T., Matsuda H., Ninomiya K., Yoshikawa M. (2002). Medicinal foodstuffs. XXIX. Potent protective effects of sesquiterpenes and curcumin from Zedoariae rhizoma on liver injury induced by D-alactosamine/lipopolysaccharide or tumor necrosis factor-α. Biological & Pharmaceutical Bulletin, 25, 627-631.
- Ogunwande I.A., Olawore N.O., Ekundayo O., Walker T.M., Schmidt J.M., Setzer W.N. (2005). Studies on the essential oils composition, antibacterial and cytotoxicity of Eugenia uniflora L. International Journal of Aromatherapy, 15, 147-152.
- Srivastava A.K., Srivastava S.K., Syamsundar K.V. (2006). Volatile composition of Curcuma angustifolia Roxb. rhizome from central and southern India. Flavour and Fragrance Journal, 21, 423-426.
- Yamazaki M., Maebayashi Y., Iwase N., Kaneko T. (1989). Germacrone as central nervous system depressant. Japanese. Kokai Tokkyo Koho, JP01139527, 8 pp.