2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (609-612)
АУТОР(И) / AUTHOR(S): Ana Ivanović-Šašić, Stevan Maćešić, Jelena Maksimović, Željko Čupić, Ljiljana Kolar-Anić
Е-АДРЕСА / E-MAIL: ana.ivanovic.sasic@ihtm.bg.ac.rs
DOI: 10.46793/ICCBI23.609IS
САЖЕТАК / ABSTRACT:
It is well known that almost all living or biological systems are naturally in the oscillatory dynamic states and can be considered as biochemical reaction systems. These oscillatory dynamic states can be caused by internal self-organized phenomena, but also by external periodic variations of temperature, light, food, or seasonal changes. The hypothalamic-pituitary-thyroid (HPT) axis is one such nonlinear system with feedback that is always in an oscillatory dynamic state and L-tyrosine is its main representative.
The biological importance of L-tyrosine interactions with iodine species was the motivation for modelling of the oscillatory dynamics in the Bray-Liebhafsky (BL) reaction perturbed by L-tyrosine. Also, direct experimental investigation of metabolic processes in the human body is extremely complex to be done, and therefore any alternative approach is of great importance. Therefore, the BL reaction has the potential to be used as a model of the biological system due to certain characteristics shared with the considered processes; it is characterized by its oscillatory dynamics and based on the chemistry of hydrogen peroxide and iodine compounds commonly present in the thyroid gland, where L-tyrosine is iodinated.
The impact of L-tyrosine on the dynamics of the Bray-Lienbhafsky oscillatory reaction was investigated numerically using the proposed model. The study was focused on the examination of the sensitivity of the BL reaction to L-tyrosine perturbation. The obtained results indicated possible pathways of influence.
КЉУЧНЕ РЕЧИ / KEYWORDS:
Numerical simulation, Bray-Liebhafsky oscilattory reaction, L-tyrosine
ЛИТЕРАТУРА / REFERENCES:
- W.C. Bray, H.A. Liebhafsky, Reactions involving hydrogen peroxide, iodine and iodate ion. I Introduction, J America Chemical Society, 53 (1931)38-44.
- Lj. Kolar-Anić, Đ. Mišljenović, S. Anić, G. Nicolis, The infuence of the reduction of iodate ion by hydrogen peroxide on the model of the Bray-Liebhafsky reaction. Reaction Kinetics Catalysis Letters, 54 (1995) 35–41.
- H.B. Dunford, I.N. Ralston, On the Mechanism of iodination of tyrosine, Biochem. Biophys. Res. Commun. 116 (1983) 639-643.