2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (519-522)
АУТОР(И) / AUTHOR(S): Ana Rilak Simović, Milica Međedović, Dejan Lazić, Milan Vraneš, Ghodrat Mahmoudi, Biljana Petrović
Е-АДРЕСА / E-MAIL: anarilak@kg.ac.rs
DOI: 10.46793/ICCBI23.519RS
САЖЕТАК / ABSTRACT:
New mononuclear Ru(II)-thienyl-terpyridine complex [Ru(thienyl-tpy)(bpy)Cl]Cl (where thienyl-tpy = 4’-(2-thienyl)-2,2’:6’,2’’-terpyridine, bpy = 2,2’-bipyridine) has been synthesized and then characterized through elemental analysis, followed by various spectroscopic (IR, UV−vis, 1H and 13C NMR) and mass spectrometric technique (ESI Q-TOF MS). Furthermore, the interactions with CT DNA were performed both in the absence and presence of biocompatible ionic liquids 1-amino-2-propanol-lactate (IL1), 1-amino-2-propanol-oxalate (IL2) and 1-amino-2-propanol-citrate (IL3).
КЉУЧНЕ РЕЧИ / KEYWORDS:
Ruthenium(II), thienyl-terpyridine, ionic liquids, DNA
ЛИТЕРАТУРА / REFERENCES:
- A.R. Simović, R. Masnikosa, I. Bratsos and E. Alessio., Chemistry and reactivity of ruthenium(II) complexes: DNA/protein binding mode and anticancer activity are related to the complex structure, Coordination Chemistry Reviews, 398 (2019) 113011.
- E. Alessio, Bioinorganic Medicinal Chemistry, Wiley-VCH Verlag & Co. KGaA, Weinheim, Germany, 2011 J. Schaff, C.C. Fink, B. Slepohenko, J.H. Carson, L.M. Loew., A General Computational Framework for Modeling Cellular Structure and Function, Biophysical Journal, 73 (1997) 1135-1146.
- W. Zheng, Y. Zhao, Q. Luo, Y. Zhang, K. Wu, F. Wang., Science China Chemistry, Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes, 59 (2016) 1240–1249.
- S. Leijen, S. A. Burgers, P. Baas, D. Pluim, M. Tibben, E. van Werkhoven, E. Alessio, G. Sava, J. H. Beijnen, J. H. M. Schellens., Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy, Investigational New Drugs, 33 (2015) 201–214.
- F. Lentz, A. Drescher, A. Lindauer, M. Henke, R. A. Hilger, C. G. Hartinger, M. E. Scheulen, C. Dittrich, B. K. Keppler, U. Jaehde., Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study, Anti-Cancer Drugs, 20 (2009) 97–103.
- M. Međedović, A. Rilak Simović, D. Ćoćić, L. Senft, S. Matić, D. Todorović, S. Popović, D. Baskić, B. Petrović., New ruthenium(II) complexes with quinone diimine and substituted bipyridine as inert ligands: synthesis, characterization, mechanism of action, DNA/HSA binding affinity and cytotoxic activity, Dalton Transactions, 52 (2023) 1323–1344.