2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (467-470)
АУТОР(И) / AUTHOR(S): Vanja Ralić, Maja Nešić, Anamarija Abu el Rub, Tanja Dučić, Branislava Gemović, Manuel Algarra, Milutin Stepić, Lela Korićanac, Jelena Žakula, Marijana Petković
Е-АДРЕСА / E-MAIL: vanja.ralic@live.com
DOI: 10.46793/ICCBI23.467R
САЖЕТАК / ABSTRACT:
Nanocomposite system formulated from surface-modified S-doped carbon dot (S-CD) nanoparticle with a potential metallodrug, palladium(II) complex, dichloro(1,2-diaminocyclohexane)palladium(II), [Pd(dach)Cl2] (Pd@S-CD), was investigated as a model system for the treatment of cervical carcinoma (HeLa) cells. To examine the intracellular biochemical effects induced by the Pd@S-CD, we used Synchrotron Radiation-based Fourier-transform infrared spectroscopy (SR FTIR). SR FTIR spectroscopy was employed to investigate the alterations in cellular components’ biochemical composition and secondary structure upon exposure to Pd@S-CD. Spectral analysis, complemented by statistical techniques, revealed changes in biomolecules, lipids, proteins, nucleic acids, and carbohydrates caused by the treatment with Pd@CDs. These results and the increased cytotoxicity of the system demonstrate its high anti-cervical cancer therapeutic potential.
КЉУЧНЕ РЕЧИ / KEYWORDS:
transition metal complex, Synchrotron Radiation, Fourier Transform Infrared Spectroscopy, nanocomposite
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