2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (443-446)
АУТОР(И) / AUTHOR(S): Martina Kepeňová, Michaela Benediková, Mária Vilková, Miroslava Litecká, Ivan Potočňák
Е-АДРЕСА / E-MAIL: martina.kepenova@upjs.student.sk
DOI: 10.46793/ICCBI23.443K
САЖЕТАК / ABSTRACT:
Four commercially unavailable derivatives of 8-hydroxyquinoline with different functional groups (nitro and halogen) in positions 5 and 7 were prepared: 5-nitro-7-iodo-8-hydroxyquinoline (HNIQ), 5-nitro-7-bromo-8-hydroxyquinoline (HNBrQ), 5-iodo-7-bromo-8-hydroxyquinoline (HIBrQ) and 5-chloro-7-bromo-8-hydroxyquinoline (HClBrQ). Their characterization was performed by IR and NMR spectroscopy, elemental analysis and in the case of HIBrQ and HClBrQ by single crystal X-ray structure analysis. Prepared compounds were used for the synthesis of new palladium(II) complexes NH2(CH3)2[PdCl2(XQ)], where XQ = NIQ (1), NBrQ (2), IBrQ (3) and ClBrQ (4). IR and NMR spectroscopy, elemental and X-ray structure analysis were used for their characterization. Bidentate chelate coordination of one molecule of XQ through nitrogen and oxygen atoms in square planar complexes was found. These complexes represent a group of compounds in which biological activities were found and will be used for the following biological study.
КЉУЧНЕ РЕЧИ / KEYWORDS:
palladium(II) complexes, 8-hydroxyquinoline, nitro and halogen derivatives of 8-hydroxyquinoline
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