2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (439-442)
АУТОР(И) / AUTHOR(S): Michaela Harmošová, Martin Kello, Mária Vilková, Erika Samoľová, Ivan Potočňák
Е-АДРЕСА / E-MAIL: michaela.krescankova@upjs.student.sk
DOI: 10.46793/ICCBI23.439H
САЖЕТАК / ABSTRACT:
The Schiff base 2-{[(2-hydroxyphenyl)imino]methyl}quinolin-8-ol (HLH) and its 5,7-dibromo- (HBrLH) and 5,7-diiodo-derivatives (HILH), which were prepared by multi-step organic synthesis, were used to synthesize [Zr(L)2]·2DMF (1), [Zr(BrL)2]·DMF (2), and [Zr(IL)2]·2DMF (3) complexes. The prepared products were characterized by elemental analysis, IR and NMR spectroscopy, which also monitored the stability of the prepared substances in DMSO, and in the case of HBrLH, HILH and 3, also by single crystal X-ray structural analysis. In the complex 3, two IL ligands are tetradentately bound to the central zirconium(IV) atom via two oxygen and two nitrogen atoms. DMF molecules are outside the coordination sphere. In complexes 1 and 2, we assume an analogous structure. Due to poor solubility, the in vitro cytostatic activity of only complex 2 and its ligand HBrLH was studied against 8 cancer cell lines of different origin (cervix, colon, pancreas, skin, breast, lung, liver and blood) and their selectivity was studied against healthy cell line BJ-5t (human dermal fibroblasts). HBrLH is comparably active to the reference drug, cisplatin, but complex 2 showed lower biological activity. Selectivity of 2 or HBrLH was not observed.
КЉУЧНЕ РЕЧИ / KEYWORDS:
zirconium, 8-hydroxyquinoline, cytotoxic activity
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