2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (419-422)
АУТОР(И) / AUTHOR(S): Mirjana B. Čolović, Lela B. Korićanac, Jelena J. Žakula, Nada Savić, Tatjana Parac-Vogt, Danijela Z. Krstić
Е-АДРЕСА / E-MAIL: colovicm@vin.bg.ac.rs
DOI: 10.46793/ICCBI23.419C
САЖЕТАК / ABSTRACT:
The objective of this study was to evaluate in vitro the antitumor properties of Fe(III)-substituted monolacunary Wells-Dawson polyoxotungstate, K7[FeIII(α2-P2W17O61)(H2O)] (FeWD) using cervical carcinoma HeLa cells as a model system. HeLa cells were exposed in vitro to FeWD within the concentration range from 0.001 to 1 mM, for 24, 48, and 72 hours. The studied Fe(III)- substituted polyoxotungstate affected HeLa cell viability in a concentration- and time-dependent manner. The obtained IC50 values (μM), as an indicator of the cytotoxic potential of FeWD, were: 16.64 ± 0.49, 10.75 ± 0.97, and 9.64 ± 0.19 for 24-, 48-, and 72-hour treatment, respectively. FeWD exhibited a stronger antitumor potential against HeLa cells than the structurally similar monolacunary Wells-Dawson polyoxotungstate, K10P2W17O61.20H2O (lacunary WD). Lacunary WD achieved IC50 at 24,11 μM after 24-hour exposure, which is about 44% higher concentration compared to the corresponding IC50 obtained for FeWD. This indicates that incorporating Fe(III) might be a new strategy for improving the antitumor efficacy of polyoxometalates as promising candidates for next-generation chemotherapeutics.
КЉУЧНЕ РЕЧИ / KEYWORDS:
Fe(III)-substituted polyoxotungstate, HeLa cells, in vitro cytotoxicity, metallodrugs, Wells-Dawson
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