2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (296-299)
АУТОР(И) / AUTHOR(S): Vanja Ralić, Branislava Gemović, Maja D. Nešić, Iva Popović, Milutin Stepić, Marijana Petković
Е-АДРЕСА / E-MAIL: vanja.ralic@live.com
DOI: 10.46793/ICCBI23.296R
САЖЕТАК / ABSTRACT:
In this work, we have applied the Informational Spectrum Method (ISM) to discover a potential protein target in the HeLa cervical cancer cell line for [Pd(dach)Cl2] complex. Since Pd complexes are considered an alternative to traditionally used Pt complexes in anti-cancer therapy, it is essential to elucidate the mechanism of their action. A detailed analysis that also involves screening the known protein databases revealed the proteins of the SOSS complex as the most probable [Pd(dach)Cl2] targets. Since this protein maintains genomic stability, this result shows the potential of the Pd(II) complex as an anti-cancer drug.
КЉУЧНЕ РЕЧИ / KEYWORDS:
Informational Spectrum Method, Cervical Cancer, palladium complex, SOSS protein
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