2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (144-147)
АУТОР(И) / AUTHOR(S): Milos Dordevic, Konstantinos Chatzipapas, Ngoc Hoang Tran, Dousatsu Sakata, Ivan Petrovic, Aleksandra Ristic-Fira, Sara Zein, Jeremy M.C. Brown, Ioanna Kyriakou, Dimitris Emfietzoglou, Susanna Guatelli, Sebastien Incerti
Е-АДРЕСА / E-MAIL: mdjordjevic@vin.bg.ac.rs
DOI: 10.46793/ICCBI23.144D
САЖЕТАК / ABSTRACT:
The scientific community has a large interest in the studies of DNA damage and response after exposure to ionizing radiation. Several in-silico methods have been proposed so far to model and study the mechanisms of DNA damage using Monte Carlo simulations. The “molecularDNA” example is one of the most recent applications to simulate the irradiation of human cancer cells and bacteria using Geant4-DNA. This example enables the simulation of the physical, physico-chemical and chemical stages of liquid water irradiation, including radiolytic processes following the particle irradiation of the pre-defined human cell geometries and it can be used to calculate the early direct and non-direct DNA damage such as single (SSB) and double strand breaks (DSB) as well as DNA fragment distribution. The application is user friendly and can be used following simple macro commands. The results of the Monte Carlo simulation are compared to experimental data of DSB yields, as well as with previously published simulation data.
КЉУЧНЕ РЕЧИ / KEYWORDS:
Geant4-DNA, Monte Carlo simulation, cancer, protons, helium ions
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