Targeting depression via computational approaches to design new coumarin-based serotonin receptor antagonists/agonists and develop reliable models of G protein-coupled receptors

2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (10-13)

АУТОР(И) / AUTHOR(S): Bartosz Trzaskowski, Kinga Ostrowska

Е-АДРЕСА / E-MAIL: b.trzaskowski@cent.uw.edu.pl

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DOI: 10.46793/ICCBI23.010T

САЖЕТАК / ABSTRACT:

It has been over 60 years since the pharmacological mechanisms of action of antidepressant drugs and the role of serotonin, norepinephrine, and dopamine in depression and other neurological disorders have been established. Since then, a very large number of chemical compounds targeting among others, serotonin and dopamine receptors have been developed. Here we present the most recent approaches to design and develop a new class of coumarin- based candidates for antidepressants with the help of computational studies.

КЉУЧНЕ РЕЧИ / KEYWORDS:

serotonin, G protein-coupled receptors, modelling, depression, coumarins

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