Investigation of the cytotoxic and apoptotic effects of the newly synthesized benzofuran-linked chalcone compounds in breast cancer

АУТОР(И) / AUTHOR(S): Yasin Polat, Aysen Sagnak, Demet Coskun, Oguzhan Akgun, Ferda Ari

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DOI:  10.46793/ICCBIKG25.577P

САЖЕТАК / ABSTRACT:

Nowadays, cancer is still one of the most important deadly diseases. Many different compounds have been developed for use in cancer treatments. Chalcone complexes, derived from the flavonoid family, are also the compounds with anticancer activity. Chalcone complexes typically exhibit anticancer activity by inducing cell death pathways and inhibiting cell proliferation. These complexes, which are known to be effective in various types of cancer based on several studies, are also known to be effective in lung, colon, and breast cancer cell lines. However, the mechanism of action of the three newly synthesized benzofuran-linked chalcone complexes (Chalcone I, Chalcone II, and Chalcone III) in these types of cancer is unknown. In this study, the cytotoxic effects of the newly synthesized chalcone compounds were investigated in lung (A549), colon (HCT116), and breast cancer (MCF7 and MDA-MB-231) cell lines. In general, chalcone complexes that inhibit cell proliferation by inducing apoptosis may also exert their effects through different death pathways. These complexes may not have anti-proliferative effects in each cancer cell line. In this context, the study demonstrated that the newly synthesized chalcone compounds exhibited no cytotoxic effect on lung (A549) and colon cancer (HCT116) cell lines, bu did Show cytotoxicity against breast cancer cell lines (MCF-7 and MDA-MB-231). In this perspective, the cytotoxic effect of the newly synthesized chalcone compound, which could be a suitable candidate for monotherapy according to the IC₅₀ value among the three different chalcone compounds used, Chalcone I, was investigated in breast cancer cell lines to determine the mechanism of death through which it acts. According to the results obtained, the newly synthesized compound was shown to cause a dose-dependent decrease in cell viability, to limit colony formation ability, and to induce cell death via apoptosis in breast cancer cell lines. According to these results, we predict that the new chalcone compound, based on its cytotoxic effect, is a candidate compound for use in monotherapy. Thus, the detailed investigation of the mechanisms of action of an artificially synthesized flavonoid-derived complex in breast cancer treatment is an important target for the development of a new cancer drug.

КЉУЧНЕ РЕЧИ / KEYWORDS:

Anticancer, Chalcone complexes, Breast cancer

ПРОЈЕКАТ / ACKNOWLEDGEMENT:

We would like to thank the Bursa Uludag Molecular Cancer Research Laboratory (BUMKAL) for their valuable support and contributions throughout this study.

ЛИТЕРАТУРА / REFERENCES:

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