3rd International Conference on Chemo and BioInformatics, Kragujevac, September 25-26. 2025. (pp. 553-556)
АУТОР(И) / AUTHOR(S): Miljan Bigović, Marija Kaluđerović, Jovana Jovanović, Nevena Prlainović, Željko Jaćimović
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DOI: 10.46793/ICCBIKG25.553B
САЖЕТАК / ABSTRACT:
Three Schiff bases were synthesized in the reaction of structurally different aromatic aldehydes and ketones with thiocarbohydrazide (TCH). The usual way of synthesizing imines (Schiff bases) between carbonyl compounds with thiocarbohydrazide involves heating them for 3 hours in a mixture of water solvents and ethanol with the addition of a catalytic amount of concentrated hydrochloric acid. The spectra of the starting compounds were recorded, so the course of the reaction and the success of the synthesis could be monitored using FTIR spectroscopy. For the Schiff bases from this work, the antioxidant activity was determined using the DPPH test, the results of which showed that the newly synthesized Schiff bases show better antioxidant activity compared to vitamin C, as a reference standard.
КЉУЧНЕ РЕЧИ / KEYWORDS:
Schiff bases, aldehydes, DPPH, antioxidant potential
ПРОЈЕКАТ / ACKNOWLEDGEMENT:
ЛИТЕРАТУРА / REFERENCES:
- L. G. Wade, Organic chemistry, Pearson; New York, 2013.
- B. Chopra, A. K. Dhingra, R. P. Kapoor, D. N. Parsad, Synthesis and antimicrobial activity of naphthylamine analogs having Azetidinone and thiazolidinone moiety, Journal of Exploratory Research in Pharmacology, 2/4 (2017) 105-112.
- J. Clayden, N. Greeves, S. Warren, Organic Chemistry. 2nd edition Oxford; 2001.
- A. Hameed, M. al-Rashida, M. Uroos, S. Abid Ali and K. M. Khan, Schiff bases in medicinal chemistry: a patent review (2010-2015), Expert Opinion on Therapeutic Patents, 27(1), (2016) 63–79.
- A. Kajal, S. Bala, S. Kamboj, N. Sharma and V. Saini, Schiff Bases: A Versatile Pharmacophore, Journal of Catalysts (2013) 1–14.
- Y. Kaya, F. Karipcin, Synthesis, characterization, antioxidant and antimicrobial studies of some Schiff base derivatives, Transition Metal Chemistry, 36 (2011) 387–395.
- a) A. Metwally, E. Khalifa, M. Koketsu, Thiocarbohydrazides: Synthesis and reactions, American Journal of Chemistry, 2 (2012) 38-51. b) J. Zhou, D. Wu, J. Gou, Optimization of the production of thiocarbohydrazide using the Taguchi method, Chemistry Technology Biotechnology 85 (2010) 1402–
- K. Gangarapu, S. Manda, A. Jallapally, S. Thota, S. Karki, J. Balzarini, E. Clercq, H. Tokuda, Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents, Medical and Chemical Research 23 (2014) 1046–1056.
- M. S. M. Alger, Polymer science dictionary. Springer. (1997) 152.
- K. Mishra, H. Ojha and N. K. Chaudhury, Estimation of antiradical properties of antioxidants using DPPH assay: A critical review and results, Food Chemistry, 130(4) (2012) 1036–1043.
- F. Rivero-Cruz, J. Granados-Pineda, J. Pedraza-Chaverri, J. M. Pérez-Rojas, A. Kumar-Passari, et al., Phytochemical Constituents, Antioxidant, Cytotoxic, and Antimicrobial Activities of the Ethanolic Extract of Mexican Brown Propolis, Antioxidants, 9 (70) (2020) 2-11.
- G. Mazzone, A. Galano, J.R. Alvarez-Idaboy and N. Russo, Coumarin-Chalcone Hybrids as Peroxyl Radical Scavengers: Kinetics and Mechanisms, Journal of Chemical Information and Modeling, 56 (2016) 662-670.