3rd International Conference on Chemo and BioInformatics, Kragujevac, September 25-26. 2025. (pp. 541-544)
АУТОР(И) / AUTHOR(S): Tamara Todorović, Jovana Muškinja, Nikola Srećković, Vladimir Mihailović, Violeta Marković
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DOI: 10.46793/ICCBIKG25.541T
САЖЕТАК / ABSTRACT:
A series of novel ferrocenyl pyrazolines containing sulfonamide moiety was prepared in a two-step reaction. All new derivatives were characterized by NMR spectroscopy and physical data. The antifungal potential of the synthesized ferrocenyl pyrazolines was evaluated on different fungal species, with several compounds exhibiting moderate antifungal effects. Notably, compounds exhibited MIC values in the range of 0.5–2 mg/mL against Penicillium canescens and Candida albicans, indicating selective antifungal activity and potential for further development as antifungal agents.
КЉУЧНЕ РЕЧИ / KEYWORDS:
antifungal activity, ferrocene, pyrazolines, sulfonamides, synthesis
ПРОЈЕКАТ / ACKNOWLEDGEMENT:
This research is funded by the Ministry of Education and Ministry of Science, Technological Development and Innovation, Republic of Serbia, Grants: Nos. 451-03- 136/2025-03/200378, 451-03-136/2025-03/200122.
ЛИТЕРАТУРА / REFERENCES:
- M. Yusuf P. Jain, Synthetic and biological studies of pyrazolines and related heterocyclic compounds, Arabian Journal of Chemistry, 7 (2014), 553-596.
- A. Ozdemir, G. TuranZitouni, Z. A. Kaplancıklı, G. Revial, K. Guven, Synthesis and Antimicrobial Activity of 1-(4-aryl-2-thiazolyl)-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives, European Journal of Medicinal Chemistry, 42 (2007), 403-409.
- R. Aggarwal, Bansal, Molecular Modeling Study of 5-Trifluoromethyl-D2-Pyrazoline and isomeric 5/3-trifluoromethylpyrazole derivatives as Anti-inflammatory agents, European Journal of Medicinal Chemistry, 70 (2013), 350-357.
- G. H. Elgemeie, R. A. Azzam, R. E. Elsayed., Sulfa drug analogs: new classes of N-sulfonyl aminated azines and their biological and preclinical importance in medicinal chemistry (2000–2018), Medicinal Chemistry Research, 28 (2019), 1099–1131.
- A. Weber, A. Casini, A. Heine, D. Kuhn, C. T. Supuran, A. Scozzafava, G. Klebe, Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition, Journal of Medicinal Chemistry, 47 (2004), 550–557.
- C. Camoutsis, A. Geronikaki, A. Ciric, M. Soković, P. Zoumpoulakis, M. Zervou, Sulfonamide- 1,2,4-thiadiazole derivatives as antifungal and antibacterial agents: synthesis, biological evalua tion, lipophilicity, and conformational studies, Chemical and Pharmaceutical Bulletin, 58 (2010), 160– 167.
- N. Srećković, J. Katanić Stanković, S. Matić, N. Mihailović, P. Imbimbo, D. M. Monti, V. Mihailović, Lythrum salicaria L. (Lythraceae) as a promising source of phenolic compounds in the modulation of oxidative stress: Comparison between aerial parts and root extracts, Industrial Crops and Products, 155 (2020), 112781.
- NCCLS, Reference method for broth dilution antifungal susceptibility testing of yeasts; Approved standard (2nd ed.), NCCLS document M27-A2, National Committee for Clinical Laboratory Standards, Wayne, PA, USA, 22 (2002).
- R. Rubbiani, O. Blacque, G. Gasser, Sedaxicenes: potential new antifungal ferrocene-based agents?, Dalton Transactions, 45 (2016), 6619-6626.