3rd International Conference on Chemo and BioInformatics, Kragujevac, September 25-26. 2025. (pp. 453-456)
AUTOR(I) / AUTHOR(S): Ana Kesić, Andrija Gigić, Mirjana Grujović, Katarina Marković, Nikola Srećković, Dragana Stevanović, Jovana Bugarinović, Jovana Bogojeski
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DOI: 10.46793/ICCBIKG25.453K
SAŽETAK / ABSTRACT:
The increasing resistance of Pseudomonas aeruginosa to conventional antibiotics necessitates the exploration of novel antimicrobial strategies. This study aimed to evaluate the potential synergistic effects of three copper-based metal complexes (Cu1–Cu3) in combination with an extract of Lythrum salicaria against P. aeruginosa. The antimicrobial efficacy of the individual agents and their combinations was assessed through determination of minimum inhibitory concentrations (MICs) and calculation of the fractional inhibitory concentration index (FICI). The results demonstrated that all tested combinations exhibited an indifferent interaction (FICI between 0.5 and 4), indicating neither synergistic nor antagonistic effects. These findings suggest that, under the tested conditions, the combined application of copper complexes and L. salicaria extract does not enhance antibacterial efficacy against P. aeruginosa, although each agent retains individual antimicrobial potential.
KLJUČNE REČI / KEYWORDS:
copper(II), synergistic effect, plant extract, antimicrobial activity
PROJEKAT / ACKNOWLEDGEMENT:
This research is funded by the Ministry of Education and Ministry of Science, Technological Development and Innovation, Republic of Serbia, Grants: No. 451-03- 136/2025-03/200378 and 451-03-136/2025-03.
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