3rd International Conference on Chemo and BioInformatics, Kragujevac, September 25-26. 2025. (pp. 407-411)
АУТОР(И) / AUTHOR(S): Ivan Ristić, Marija Krstić, Nikola Geskovski, Aleksandra Ivanoska-Dacikj, Petre Makreski, Nina Jokić, Jelena Tanasić
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DOI: 10.46793/ICCBIKG25.407R
САЖЕТАК / ABSTRACT:
Biomaterials designed for wound management must simultaneously meet a complex set of criteria, including biocompatibility, mechanical flexibility, and responsiveness to physiological conditions. In this study, we report the synthesis and detailed characterization of a series of biodegradable polyurethanes (PU) developed as functional biomaterials for integration into smart wound dressings intended for biomedical use. The PUs were obtained via a two-step polymerization process using bio-based polyols (synthesized polyricinoleate and commercial polycaprolactone) and 1,4-butanediol as a chain extender, with diphenylmethane diisocyanate serving as the hard segment. This approach enabled the design of PU materials with a tailored molecular structure and tunable properties suitable for use in drug-delivering and barrier layers of wound dressings. FTIR spectroscopy confirmed the successful incorporation of urethane linkages and desired polymer structure formation. DSC revealed a thermally stable and amorphous polymer structure, desirable for in vivo applications. Mechanical testing showed that the obtained PUs exhibit high elasticity, with elongation at break exceeding 400% and tensile strength up to ~5 MPa, suggesting strong potential for load-bearing soft tissue support and dynamic biomedical environments. Biocompatibility was assessed via in vitro cytotoxicity testing using human fibroblasts and the MTT assay, demonstrating high cell viability and the absence of cytotoxic effects. These results position the developed PUs as safe and effective biomaterials for further exploration in regenerative medicine, particularly in the field of advanced wound care, where flexible, bioresorbable, and non-toxic materials are in high demand.
КЉУЧНЕ РЕЧИ / KEYWORDS:
polyurethanes, wound healing, biomaterials, biocompatibility
ПРОЈЕКАТ / ACKNOWLEDGEMENT:
Authors would like to thank the NATO SPS program, project G6031-”Wearable Smart Patches for Multimodal Wound Healing – DRESWOUTRE” for financial support.
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