Integration of 3D Printing Technologies with Deuterated Polyunsaturated Fatty Acids (D-PUFAs)

АУТОР(И) / AUTHOR(S): Djordje Milosevic, Marija Brankovic, Nevena Mihailovic, Fatima Zivic

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DOI:  10.46793/ICCBIKG25.386M

САЖЕТАК / ABSTRACT:

Deuterated polyunsaturated fatty acids (D-PUFAs) represent a novel class of bioactive lipids characterized by enhanced oxidative stability and promising therapeutic potential. Although direct research on integrating D-PUFAs with 3D printing technologies remains limited, this paper discusses the emerging opportunities for their use with these stable lipids. By drawing on similar studies with conventional PUFAs and other bioactive compounds, this paper highlights their chemical properties, availability, and potential compatibility with different biomaterials and substrates suitable for 3D printing applications. 3D bioprinting has enabled development of tailored carriers, scaffolds, and functional systems that can help improve product stability, enable more controlled release, and potentially enhance overall performance. This conceptual overview presents current developments, knowledge gaps, possible material combinations and processing strategies to incorporate D-PUFAs into 3D printed constructs, focusing on cosmetics applications. Finally, future research directions are discussed, emphasizing material requirements, processing conditions, and characterization techniques essential for real-case implementation.

КЉУЧНЕ РЕЧИ / KEYWORDS:

D-PUFAs, 3D printing, Oxidative Stability, Drug Delivery, Cosmetic applications

ПРОЈЕКАТ / ACKNOWLEDGEMENT:

This paper is supported through the EIT’s Higher Education Initiative SMART-2M, DEEPTECH-2M and A-SIDE projects, coordinated by EIT RawMaterials, funded by the European Union and the i-GREENPHARM project, HORIZON-MSCA-2023-SE-01-01, Grant No. 101182850 and supported by the Ministry of Education and Ministry of Science, Technological Development and Innovation, Republic of Serbia, Grants: No. 451-03-137/2025-03/200107 and 451-03-136/2025-03/200378.

ЛИТЕРАТУРА / REFERENCES:

• K. Vithani, A. Goyanes, V. Jannin, A.W. Basit, S. Gaisford, B.J. Boyd, An overview of 3D printing technologies for soft materials and potential opportunities for lipid-based drug delivery systems, Pharmaceutical Research 36 (2019) 4.
• A. Smarun, M. Petkovic, M. Shchepinov, D. Vidovic, Site-specific deuteration of polyunsaturated alkenes, The Journal of Organic Chemistry 82 (2017) 13115–13120.
• C. R. Lamberson, L. Xu, H. Muchalski, J.R. Montenegro-Burke, V.V. Shmanai, A.V. Bekish, J.A. McLean, C.F. Clarke, M.S. Shchepinov, N.A. Porter, Unusual kinetic isotope effects of deuterium reinforced polyunsaturated fatty acids in tocopherol-mediated free radical chain oxidations, Journal of the American Chemical Society 136 (2014) 838–841.
• A. Schwab, R. Levato, M. D’Este, S. Piluso, D. Eglin, J. Malda, Printability and Shape Fidelity of Bioinks in 3D Bioprinting, Chem. Rev. 120 (2020) 11028–11055. https://doi.org/10.1021/acs.chemrev.0c00084.