Marigold – an ornamental plant with medicinal application 

Chemia Naissensis Volume 6, No.1 (2023) (стр. 82-92) 

АУТОР(И) / AUTHOR(S): Milena Nikolić, Dragana Marković Nikolić, Aleksandar Zdravković, Aleksandra Pavlović

Е-АДРЕСА / E-MAIL: milena.ivanovic@pmf.edu.rs

Download Full Pdf   

DOI: 10.46793/ChemN6.1.82N

САЖЕТАК / ABSTRACT:

Marigold (Calendula officinalis L.) is a widespread ornamental and medicinal plant with a long history of use in traditional medicine. Calendula officinalis contains many secondary metabolites that benefit human health and relieve skin ulcers and wound pain. Its essential oil is rich in monoterpenes and sesquiterpenes. Specific amounts of geraniol, limonene, thujene, and pinene in essential oil made it desirable in the cosmetics and perfume industries. Ethanolic extracts of Calendula officinalis contain flavonoids – substances with potent antioxidant properties. Due to carotenoids in flowers, Calendula officinalis extracts can be used as natural food colourants. The newest studies pointed out the potential of Calendula officinalis extracts as anti-inflammatory, anti-cancer, antibacterial and antifungal agents.

КЉУЧНЕ РЕЧИ / KEYWORDS:

Calendula officinalis, essential oil, terpenes, carotenoids, cytotoxicity

ЛИТЕРАТУРА / REFERENCES:

  • Bakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008). Biological effects of essential oils-a review. Food and Chemical Toxicology, 46, 446-475.
  • Behbahani, M. (2014). Evaluation of in vitro anticancer activity of Ocimum basilicum, Alhagi maurorum, Calendula officinalis and their parasite Cuscuta campestris. PublicLibraryof Science One, 9, e116049.
  • Efstratiou, E., Hussain, A.I., Nigam, P.S., Moore, J.E., Ayub, M.A., &Rao, J.R. (2012). Antimicrobial activity of Calendula officinalis petal extracts against fungi, as well as Gram-negative and Gram-positive clinical pathogens. Complementary Therapies in Clinical Practise,18, 173-176.
  • Kajeh, M., Yamini, Y., Sefidkon, F., &Bahramifar, N. (2004). Comparison of essential oil composition of Carum copticum obtained by supercritical carbon dioxide extraction and hydrodistillation methods.Food Chemistry, 86, 587-591.
  • Kim, S. H. Bae, H. C., Park, E. J., Lee, C., Kim, B-J., Lee, S., Park, H. H., Kim, S-J., So, I., Kim,
  • T-W., Jeon, J-H. (2011). Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways. Biochemical and Biophysical Research Communications, 407, 129-134.
  • Kishimoto, S., Maoka, T., Sumitomo, K., & Ohmiya, A. (2005). Analysis of Carotenoid Composition in Petals of Calendula (Calendula officinalis L.). Bioscience, Biotechnology, and Biochemistry, 69, 2122–2128.
  • Matysik, G., Wójciak-Kosior, M., & Paduch, R. (2005). The influence of Calendulae officinalis flos extracts on cell cultures, and the chromatographic analysis of extracts. Journal of Pharmaceutical and Biomedical Analysis, 38, 285–292.
  • Okoh, O.O., Sadimenko, A., & Afolayan, A. J. (2007). The Effects of Age on the Yield and Composition of the Essential Oils of Calendula officinalisJournal of Applied Sciences, 7, 3806- 3810.
  • Petrović, L., Lepojević, Ž., Sovilj, V., Ad. amović, D., & Tešević, V. (2007). An investigation of CO2 extraction of marigold (Calendula officinalis L.). Journal of Serbian Chemistry Society, 72, 407–413.
  • Qi, F., Yan, Q., Zheng, Z., Liu, J., Chen,Y., & Zhang, G. (2018). Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest. Journal of BUON, 23, 346-352.
  • Raal, A., Kirsipuu, K., Must, R., & Tenno, S. (2009). Content of total carotenoids in Calendula officinalis L. from different countries cultivated in Estonia. Natural Product Communication, 4, 35-38.
  • Raal, A., Orav, A., Nesterovitsch, J., & Maidla, K. (2016). Analysis of Carotenoids, Flavonoids and Essential Oil of Calendula officinalis Cultivars Growing in Estonia. Natural Product Communication, 11, 1157-1160.
  • Rigane, G., Younes, S., Ghazghazi, H., & Salem, R.B. (2013). Investigation into the biological activities and chemical composition of Calendula officinalis L. growing in Tunisia. International Food Research Journal, 20, 3001-3007.
  • Rodenak-Kladniew, B., Gambaro, R., Cisneros, J., Huck-Iriart, C., Padula, G., Castro, G., Chain, C., & Islan, G. (2023). Enhanced anticancer activity of encapsulated geraniol into biocompatible lipid nanoparticles against A549 human lung cancer cells. Journal of Drug Delivery Science and Technology, 80, 104159.
  • Sahingil, D. (2019). GC/MS-Olfactometric Characterization of the Volatile Compounds, Determination Antimicrobial and Antioxidant Activity of Essential Oil from Flowers of Calendula (Calendula officinalis L.). Journal of Essential Oil Bearing Plants, 22, 1571-1580.
  • Salehi, B., Upadhyay, S., Erdogan, I., Kumar, A., Jayaweera, S., Dias, D., Sharopov, F., Taheri, Y., Martins, N., Baghalpour, N., Cho, WC., & Sharifi-Rad, J. (2019). Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature. Biomolecules, 9, 738.
  • Shahane, K., Kshirsagar, M., Tambe, S., Jain, D., Rout, S., Ferreira, M.K.M., Mali, S., Amin, P., Srivastav, P.P., Cruz, J., & Lima, R.R. (2023). An Updated Review on the Multifaceted Therapeutic Potential of Calendula officinalis L. Pharmaceuticals, 16, 611.
  • Singh, D., Bhardwaj, S., Kumar, A., Kaushik, V., Mahajan, S., & Satija S. (2018). Antimicrobial Activity and Molecular Docking Studies of a Sesquiterpenoid Alcohol from Leaf Solvent Extracts of Juniperus communis L. International Journal of Green Pharmacy, 12, 22-28.
  • Su, Y-C., & Ho, C-L. (2013). Composition, in-vitro Anticancer, and Antimicrobial Activities of the Leaf Essential Oil of Machilus mushaensis from Taiwan. Natural Product Communications, 8, 273-275.
  • Tung, Y.T., Huang, C.C., Ho, S.T., Kuo, Y.H., Lin, C.C., Lin, C.T., & Wu, J.H. (2011). Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute hepatitis in mice. Journal of Agriculture and Food Chemistry, 59, 8117-8123.
  • Ukiya, M., Akihisa, T., Yasukawa, K., Tokuda, H., Suzuki, T., & Kimura, Y. (2006). Anti- Inflammatory, Anti-Tumor-Promoting, and Cytotoxic Activities of Constituents of Marigold (Calendula officinalis) Flowers. Journal of Natural Products, 69, 1692–1696.
  • Vinola, S.M., Sekar, M., Renganathan, S., & Dhiraviam, S. (2021). Comparative evaluation of Calendula officinalis and 2% chlorhexidine against Enterococcus faecalis  and  Candida  albicans. Journal of Interdisciplinary Dentistry, 11, 119-123.
  • Veličković J.M., Dimitrijević D.S., Mitić S.S, Mitić M.N., & Kostić D.A. (2014). The determination of the phenolic composition, antioxidative activity and heavy metals in the extracts of Calendula officinalis L. Advanced technologies, 3, 46-51.  
  • Yalgi, V.S., & Bhat, K.G. (2020). Compare and evaluate the antibacterial efficacy of sodium hypochlorite and Calendula officinalis against Streptococcus mutans as a root canal irrigating solution: An in vivo study. Journal of International Oral Health,12, 74-79.
  • Yousefi, M., Rahimi-Nasrabadi, M., Pourmortazavi, S., Wysokowski, M., Jesionowski, T., Ehrlich, H., & Mirsadeghi, S. (2019), Supercritical fluid extraction of essential oils, Trends in Analytical Chemistry, 118, 182-193.
  • https://unsplash.com/