17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume II) (2024) [O-03-SL, pp. 597]
AUTHOR(S) / АУТОР(И): Ivana Đorđević 
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DOI: 10.46793/Phys.Chem24II.597DJ
ABSTRACT / САЖЕТАК:
The amide bond is a fundamental and arguably one of chemistry and biochemistry’s most important functional groups. Furthermore, the peptide bond is one of nature’s most ubiquitous amide bond examples. It links amino acids in peptides and proteins, determining the secondary structures formation of proteins and their biological activities. It is well known that typical amides are planar due to the resonance effect, a concept introduced by Pauling nearly a century ago. The vast majority of amides contain planar bonds of approximately 40% partial double bond character as a consequence of the nN to π*C=O conjugation and resonance energy of 15−20 kcal mol−1.
KEYWORDS / КЉУЧНЕ РЕЧИ:
ACKNOWLEDGEMENT / ПРОЈЕКАТ:
This work was supported by the Ministry of Science, Innovation and Technological Development of the Republic of Serbia (grant no 451‐03‐66/2024‐03/200026).