17th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings, Volume I) (2024) [H-23-P, pp. 365-368]
AUTHOR(S) / AUTOR(I): Sandra Milinković 
, Ana Ćirić and Ljiljana Đekić
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DOI: 10.46793/Phys.Chem24I.365M
ABSTRACT / SAŽETAK:
There is great interest in development of film-forming systems for dermal (topical or transdermal) drug delivery (FFSDDD) due to their unique property to form a thin, continuous film upon administration to the skin surface, offering numerous advantages compared to conventional topical preparations. The primary research challenge in the FFSDDD development is the formulation of a carrier that represents a polymer solution in a volatile and non-volatile solvents mixture. We examined the influence of the film-forming polymer (hypromellose) concentration and the type and concentration of nonvolatile solvent (propylene glycol or macrogol 400) and volatile solvent (ethanol or isopropanol) on the physicochemical (pH and transmittance) and rheological properties of the film-forming solution (FFS) and the properties of the film formed. FFS containing 2.5% of hypromellose and 1.25% and 5% propylene glycol form films with the most desirable pH, appearance, viscosity, and flexibility, so they can be considered promising dermal drug delivery carriers.
KEYWORDS / KLJUČNE REČI:
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