Traditional Ethnobotanical Applications of Melissa officinalis for Niš district

Chemia Naissensis Volume 7, No.1 (2024) (стр. 27-39) 

АУТОР(И) / AUTHOR(S): Vesna Stankov Jovanović , Katarina Stepić , Tijana Jovanović , Slobodan Ćirić , Radomir Ljupković , Jovana Ickovski , Marija Marković

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DOI: 10.46793/ChemN7.1.27SJ

САЖЕТАК / ABSTRACT:

Melissa officinalis (lemon balm) has been utilized for centuries in traditional medicine for its diverse therapeutic properties. This study explores its traditional applications and evaluates the pharmacological evidence supporting its use in treating various ailments. The bioactive compounds present in M. officinalis, such as rosmarinic acid, flavonoids, and essential oils, are responsible for its notable effects, including anxiolytic, antimicrobial, antioxidant, and digestive benefits. Traditional uses of M. officinalis in Niš District, southeastern Serbia, spanning from alleviating stress, anxiety and sleep problems to treating gastrointestinal discomfort, align with findings from contemporary scientific research. Despite its extensive history of use and integration in modern medicinal therapeutic practices, further clinical investigations are needed to substantiate its safety, efficacy, and mechanisms of action. This paper highlights the significance of M. officinalis as a bridge between traditional knowledge and modern medicinal applications, as well as the importance of preserving traditional knowledge.

КЉУЧНЕ РЕЧИ / KEYWORDS:

Melissa officinalis, ethnobotany, medicinal plants, therapeutic effects, traditional medicine, traditional knowledge

ПРОЈЕКАТ/ ACKNOWLEDGEMENT:

This study is supported by the Ethno-pharmacological study of the region of southeastern Serbia, O-02-17, supported by the Serbian Academy of Sciences and Arts.

ЛИТЕРАТУРА / REFERENCES:

  • Abolfazl S., Sahebkar A., & Javadi B. (2016). Melissa officinalis L.–A review of its traditional uses, phytochemistry and pharmacology. Journal of ethnopharmacology, 188, 204-228, doi: 
    https://doi.org/10.1016/j.jep.2016.05.010
  • Allahverdiyev, A., Duran, N., Ozguven, M., & Koltas, S. (2004). Antiviral activity of the volatile oils of Melissa officinalis L. against herpes simplex virus type-2. Phytomedicine, 11(7–8), 657–661. https://doi.org/10.1016/j.phymed.2003.07.014
  • Arbastan, M. A., Rahzani, K., Hekmatpou, D., Alizadeh, S. A., Rafiei, M., & Malekirad, A. A. (2014). The effect of Oral Melissa officinalis; on serum oxidative stress and Second degree burn wounds healing. Health, 06(18), 2517–2524. https://doi.org/10.4236/health.2014.618290
  • Bitew M. A., Mohammed M. A., & Tefera A. K. (2022). Ethnobotanical study of traditional medicinal plants used to treat human and animal diseases in Sedie Muja District, South Gondar, Ethiopia. Evidence‐Based Complementary and Alternative Medicine, 7328613,
    https://doi.org/10.1155/2022/7328613
  • Bounihi, A., Hajjaj, G., Alnamer, R., Cherrah, Y., & Zellou, A. (2013). In Vivo Potential AntiInflammatory Activity of Melissa officinalis L. Essential Oil. Advances in pharmacological sciences, 2013, 101759. https://doi.org/10.1155/2013/101759
  • Carvalho, F., Duarte, A. P., & Ferreira, S. (2021). Antimicrobial activity of Melissa officinalis and its potential use in food preservation. Food Bioscience, 44, 101437.
    https://doi.org/10.1016/j.fbio.2021.101437
  • Cases, J., Ibarra, A., Feuillère, N., Roller, M., & Sukkar, S. G. (2010). Pilot trial of Melissa officinalis L. Leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Mediterranean Journal of Nutrition and Metabolism, 4(3), 211–218. https://doi.org/10.1007/s12349-010-0045-4
  • Cunningham, A. B. (2014). Applied ethnobotany: people, wild plant use and conservation. (1st ed.). Routledge.
  • Chung-Hsiung, H., & Jia-Yin, C. (2024). Effects of Mung Bean Water Supplementation on Modulating Lipid and Glucose Metabolism in a Diabetic Rat Model. Nutrients, 16(16), 2684.
  • Demirci, K., Akgonul, M., Demirdas, A., & Akpinar, A. (2015). Does Melissa officinalis cause withdrawal or dependence? Medical Archives, 69(1), 60. https://doi.org/10.5455/medarh.2015.69.60-61
  • Draginic N, Andjic M, Jeremic J, Zivkovic V, Kocovic A, Tomovic M, Bozin B, Kladar N, Bolevich S, Jakovljevic V, Milosavljevic I. (2022). Anti-inflammatory and Antioxidant Effects of Melissa officinalis Extracts: A Comparative Study. Iranian Journal of Pharmaceutical Research, 21(1), 126561. https://doi.org/10.5812/ijpr-126561
  • Fabricant, D. S., & Farnsworth, N. R. (2001). The value of plants used in traditional medicine for drug discovery. Environmental Health Perspectives, 109(1), 69–75, doi: 10.1289/ehp.01109s169
  • Ghazizadeh, J., Hamedeyazdan, S., Torbati, M., Farajdokht, F., Fakhari, A., Mahmoudi, J., Arajkhodaei, M., & Sadigh‐Eteghad, S. (2020). Melissa Officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis. Experimental Physiology, 105(4), 707–720. https://doi.org/10.1113/ep088254
  • https://foodly.tn/tips/4-790
  • https://www.reviewsll.com/gluco-shield-pro-review-a-comprehensive-analysis-of-the-pros-andcons/
  • Jones, Catherine M. „The transnational governance of global health: Norwegian and Swiss cases of national policies on global health.“ (2017).
  • Juee, L. Y. M., Sofi, S. H., & Adham, A. N. (2023). Melissa officinalis gastroprotective and antioxidant efficacy. Journal of Functional Foods, 105, 105550. https://doi.org/10.1016/j.jff.2023.105550
  • Kapalka, G. M. (2010). Sleep. Nutritional and Herbal Therapies for Children and Adolescents, 259–289. https://doi.org/10.1016/b978-0-12-374927-7.00009-1
  • Mimica-Dukic N., Bozin B., Soković M. & Simin N. (2004). Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil. Journal of agricultural and food chemistry, 52, 2485-2489, doi: https://doi.org/10.1021/jf030698a
  • Miraj, S., Rafieian-Kopaei and Kiani, S. (2016) ‘Melissa Officinalis L: A review study with an antioxidant prospective’, Journal of Evidence-Based Complementary & Alternative Medicine, 22(3), pp. 385–394. https://doi.org/10.1177/2156587216663433
  • Naseri, M., Arabi Mianroodi, R., Pakzad, Z., Falahati, P., Borbor, M., Azizi, H., & Nasri, S. (2021). The effect of Melissa officinalis L. extract on learning and memory: Involvement of hippocampal expression of nitric oxide synthase and brain-derived neurotrophic factor in diabetic rats. Journal of Ethnopharmacology, 276, 114210. https://doi.org/10.1016/j.jep.2021.114210
  • Sepide M., Kopaei R., & Kiani S. (2017). Melissa officinalis L: A Review study with an antioxidant prospective. Journal of evidence-based complementary & alternative medicine, 223, 385-394, doi: https://doi.org/10.1177/2156587216663433
  • Sharifi-Rad J., Quispe C., Herrera-Bravo J., Akram M., Abbaass W., Semwal V., Painuli S., Alekseevich Konovalov D., Alfred M. A., Kumar N., Imran M., Nadeem M., Sawicka B., Pszczółkowski P., Bienia B., Barbaś B., Mahmud S., Durazzo A., Lucarini M., Santini A., Martorell M., Calina D. (2021)., „[Retracted] Phytochemical Constituents, Biological Activities, and Health‐Promoting Effects of the Melissa officinalis. Oxidative Medicine and Cellular Longevity, 6584693, doi: https://doi.org/10.1155/2021/6584693
  • Stojanović, N. M., Mladenović, M. Z., Randjelović, P. J., & Radulović, N. S. (2023). The potential of lemon balm (Melissa officinalis L.) essential oil as an anti-anxiety agent – is the Citronellal the activity carrier? Journal of Ethnopharmacology, 314, 116661.
    https://doi.org/10.1016/j.jep.2023.116661