Synthesis and cytotoxic activity of selected dual COX-2 and 5-LOX inhibitors in HeLa and MIA PaCa-2 human cancer cell lines

2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (503-506)

АУТОР(И) / AUTHOR(S): Otilija Keta, Jelena Bošković, Vladana Petković, Neda Đorđević, Vladimir Dobričić, Olivera Čudina, Snežana B. Pajović

Е-АДРЕСА / E-MAIL: otilijak@vin.bg.ac.rs

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DOI: 10.46793/ICCBI23.503K

САЖЕТАК / ABSTRACT:

Among novel cancer chemotherapy approaches, the use of cyclooxygenases (COXs) and lipoxygenases (LOXs) inhibitors represents a promising mean for cancer treatment showing lesser toxicity comparing to the currently used cytotoxic drugs. This study detailed the synthesis of three novel compounds: 1ME, BHTK-AA, and IBU-Ac, each with the capability to concurrently inhibit both COX-2 and 5-LOX. Subsequently, we assessed their effectiveness in inhibiting the proliferation of HeLa cervical and MIA PaCa-2 pancreatic cancer cells. The IC50 values for both examined cell lines were approximately 40 μM, indicating the promising inhibitory potential of the IBU-Ac compound in both types of cancer cells. This finding is positioned to stimulate further investigation into the potential application of IBU-Ac against these particular types of cancers, while also advocating its use in combination with standard anti-cancer protocols, i.e., chemoterapeutics or radiation therapy. The results of this work are also advocating the development and refinement of dual COX-2 and 5-LOX inhibitors, thus improving their efficacy and safety.

КЉУЧНЕ РЕЧИ / KEYWORDS:

cancer, dual COX-2 and 5-LOX inhibitors, cytotoxicity

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