2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (471-474)
АУТОР(И) / AUTHOR(S): Otilija Keta, Vladana Petković, Neda Đorđević, Miloš Đorđević, Branka Ivković, Vladimir Dobričić
Е-АДРЕСА / E-MAIL: vanja.ralic@live.com
DOI: 10.46793/ICCBI23.471K
САЖЕТАК / ABSTRACT:
Given the well-established potential of chalcones in modulating the response of cancer cells to therapeutic interventions, coupled with the growing imperative to enhance their biological attributes, the objective of this study was to synthesize a methoxy-substituted chalcone (OCH3) and assess its capacity to amplify the inhibitory effects of radiation in melanoma cells known for their resistance to radiotherapy. The A375 melanoma cells were subjected to a clinically relevant dose of 2 Gy gamma irradiation. OCH3 was employed either as a standalone treatment or in conjunction with irradiation. The obtained results unveiled the substantial radiosensitizing potential of OCH3 within this specific cell line. Our subsequent investigations will be designed to investigate the underlying mechanisms that contribute to the radiosensitizing properties of OCH3. Moreover, we intend to evaluate the efficacy of OCH3 against other types of radioresistant cancer cells. The presented data not only illuminates the enhanced therapeutic possibilities offered by OCH3 but also highlights its potential as a valuable agent in addressing a wider array of challenging malignancies.
КЉУЧНЕ РЕЧИ / KEYWORDS:
methoxy substituted chalcone, melanoma, irradiation
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