2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (447-450)
АУТОР(И) / AUTHOR(S): Jakub Kurjan, Rastislav Jendželovský, Zuzana Jendželovská, Viktória Buľková, Mária Vilková, Miroslava Litecká, Ivan Potočňák
Е-АДРЕСА / E-MAIL: jakubkurjan@upjs.student.sk
DOI: 10.46793/ICCBI23.447K
САЖЕТАК / ABSTRACT:
In this contribution, a novel coumarin-derivative ligand, and its silver(I) complex are reported. Ligand 3-(1-(2-pyridylamino)ethylidene)-2H-chromene-2,4-dione (HL) was prepared by reaction of 3-acetyl-4-hydroxycoumarin with 2-picolyl amine. Further, complex [Ag(HL)2]NO3 was prepared and both compounds were characterized by physico-chemical methods such as IR and NMR spectroscopy, elemental analysis, and structure of the ligand and the complex was confirmed by X-ray analysis. The stability of both compounds was measured by NMR spectroscopy. MTT assay and cell proliferation assay on human lung adenocarcinoma cell line A549 and human colorectal adenocarcinoma cell line HT-29 showed that complex was more active than free HL ligand.
КЉУЧНЕ РЕЧИ / KEYWORDS:
coumarin, silver, anticancer
ЛИТЕРАТУРА / REFERENCES:
- E. H. AVDOVIĆ, et al., Synthesis, Characterization and Cytotoxicity of a new Palladium(II) Complex with a Coumarin-Derived Ligand 3-(1-(3-hydroxypropylamino)ethylidene)chroman-2,4-dione. Crystal structure of the 3-(1-(3-hydroxypropylamino)ethylidene)-chroman-2,4-dione, Inorganica Chimica Acta, 466 (2017) 188-196.
- R. S. KUMAR, et al., Silver Complexes as Anticancer Agents: A Perspective Review, German J Pharm Biomaterials, 1 (2022) 6-28.
- BALCIOĞLU, S. et al., Therapeutic potential of coumarin bearing metal complexes: Where are we headed?, Bioorganic and Medicinal Chemistry letters, 30 (2020) 1135-1146.
- S. SUKDOLAK, et al., Hantzsch reaction of 3-(2-bromoacetyl)-4-hydroxy-chromen-2-one. Synthesis of 3-(thiazol-4-yl)-4-hydroxy coumarines., Journal of Heterocyclic Chemistry, 41 (2004) 593-596