3rd International Conference on Chemo and BioInformatics, Kragujevac, September 25-26. 2025. (pp. 620-623)
АУТОР(И) / AUTHOR(S): Jelena R. Đorović Jovanović, Enisa S. Selimović, Violeta D. Jakovljević, Kristina D. Milisavljević, Stevan V. Sofronijević, Svetlana R. Jeremić
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DOI: 10.46793/ICCBIKG25.620DJ
САЖЕТАК / ABSTRACT:
A previously conducted experimental study demonstrated that the dinuclear Pt/Cu complex examined here can very effectively inhibit the growth and development of Enterococcus faecalis, a bacterium whose infections can lead to serious consequences and which is resistant to numerous antibiotics. The structure of the investigated complex consists of [Pt(DMEAImiPr)Cl2] on one side and [CuCl2(terpy)], connected by 4,4′-bipyridine as a bridging ligand. As the aforementioned study revealed that this complex does not inhibit the gyrase of E. faecalis, the present work investigates the mechanism of bacterial growth inhibition in the presence of this dinuclear complex by applying the molecular method. It was found that the compound effectively inhibits the hydrolases of E. faecalis, even more efficiently than Doxycycline, and that both ligands bind to these proteins at the same active sites. Therefore, it is reasonably assumed that the mechanism of E. faecalis growth inhibition by the tested complex primarily involves the inhibition of the bacterium’s hydrolases.
КЉУЧНЕ РЕЧИ / KEYWORDS:
Dinuclear Pt/Cu complex, Molecular docking, Mechanism of E. faecalis growth, Hydrolases
ПРОЈЕКАТ / ACKNOWLEDGEMENT:
This research is funded by the Ministry of Education and Ministry of Science, Technological Development and Innovation, Republic of Serbia, Grants: Nos. 451-03- 136/2025-03/200378 and 451-03-137/2025-03/200252.
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