3rd International Conference on Chemo and BioInformatics, Kragujevac, September 25-26, 2025. (pp. 27-30)
АУТОР(И) / AUTHOR(S): Xin Jin, Gang Liu, Wei Zhang
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DOI: 10.46793/ICCBIKG25.027J
САЖЕТАК / ABSTRACT:
Hydrogels are widely used for controlled drug release due to their biocompatibility, hydrophilicity, and drug-loading capacity. However, conventional hydrogels often show initial burst release followed by a decline, caused by high drug concentration gradients and uneven drug distribution. Here, we propose a multilayer sodium alginate hydrogel to improve drug release fluctuation. The drug is loaded into the inner hydrogel layers to optimize distribution, while the drug-free outer layer minimizes rapid surface desorption and reduces the concentration gradient. The system demonstrates excellent biocompatibility (>95% cell viability) and reduces the initial 2 h drug release rate by 67.4% compared to monolayer hydrogels, effectively stabilizing release fluctuations.
КЉУЧНЕ РЕЧИ / KEYWORDS:
Sodium alginate, Multilayer hydrogel, Controlled drug release
ПРОЈЕКАТ / ACKNOWLEDGEMENT:
This research is funded by the National Natural Science Foundation of China [12402370], National Key Research and Development Program of China [2022YFE0115400], and Fundamental Research Funds for the Central Universities [DUT24YG106, DUT24YG208].
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